2-CYANOMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: 2-CYANOMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS No.: 259180-69-3
• Molecular Formula: C₁₁H₁₈N₂O₃
• Molecular Weight: 226.276
• Mol file: 259180-69-3.mol

Synonyms:2-CYANOMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property of 2-CYANOMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property:

• Boiling Point: 358.3±27.0 °C(Predicted)
• PKA: -2.34±0.40(Predicted)
• PSA: 62.56000
• Density: 1.094±0.06 g/cm3(Predicted)
• LogP: 1.47388

Purity/Quality:

97% ^*data from raw suppliers

2-Cyanomethyl-morpholine-4-carboxylicAcidtert-ButylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CYANOMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER

There total 6 articles about 2-CYANOMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

potassium cyanide + (R)-tert-butyl 2-(((methylsulfonyl)oxy)methyl)morpholine-4-carboxylate (503455-76-3) → (S)-tert-butyl 2-(cyanomethyl)morpholine-4-carboxylate (259180-69-3)

Guidance literature:

With potassium iodide; In dimethyl sulfoxide; at 80 - 100 ℃; for 7h;

Reference yield: 74.4%

potassium cyanide + tert-butyl (2S)-2-{[(methylsulfonyl)oxy]methyl}morpholine-4-carboxylate (606139-90-6) → tert-butyl (2R)-2-(cyanomethyl)morpholine-4-carboxylate (259180-69-3)

Guidance literature:

With potassium iodide; In dimethyl sulfoxide; at 100 ℃; for 4h;

Reference yield:

potassium cyanide + 4-t-butoxycarbonyl-2-[(4-methylphenylsulphonyloxy)methyl]morpholine (130546-33-7) → (R)-tert-butyl 2-(cyanomethyl)morpholine-4-carboxylate (259180-69-3)

Guidance literature:

With potassium iodide; In dimethyl sulfoxide; at 80 - 100 ℃; for 5h;

upstream raw materials:

(R)-tert-butyl 2-(((methylsulfonyl)oxy)methyl)morpholine-4-carboxylate

(R)-2-hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester

tert-butyl (2S)-2-{[(methylsulfonyl)oxy]methyl}morpholine-4-carboxylate

tert-butyl (2S)-2-(hydroxymethyl)morpholine-4-carboxylate

Downstream raw materials:

(±)-tert-butyl 2-(2-aminoethyl)morpholine-4-carboxylate