4-(2-fluoro-4-((1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridin-3-yl)carbamoyl)phenoxy)picolinamide

Base Information

• Chemical Name: 4-(2-fluoro-4-((1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridin-3-yl)carbamoyl)phenoxy)picolinamide
• CAS No.: 930576-24-2
• Molecular Formula: C₂₄H₁₆F₂N₄O₄
• Molecular Weight: 462.412

Synonyms:4-(2-fluoro-4-((1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridin-3-yl)carbamoyl)phenoxy)picolinamide

Chemical Property of 4-(2-fluoro-4-((1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridin-3-yl)carbamoyl)phenoxy)picolinamide

Chemical Property:

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Technology Process of 4-(2-fluoro-4-((1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridin-3-yl)carbamoyl)phenoxy)picolinamide

There total 1 articles about 4-(2-fluoro-4-((1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridin-3-yl)carbamoyl)phenoxy)picolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

3-amino-1-(4-fluorophenyl)pyridin-2(1H)-one (930576-16-2) + 4-(2-carbamoylpyridin-4-yloxy)-3-fluorobenzoic acid (930576-23-1) → 4-(2-fluoro-4-((1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridin-3-yl)carbamoyl)phenoxy)picolinamide (930576-24-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 50 ℃; for 5h;

Reference yield: 72.0%

4-(2-fluoro-4-((1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridin-3-yl)carbamoyl)phenoxy)picolinamide (930576-24-2) → 4-(2-aminopyridin-4-yloxy)-3-fluoroN-(1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridin-3-yl)benzamide, trifluoroacetic acid salt (930576-22-0)

Guidance literature:

With pyridine; water; bis-[(trifluoroacetoxy)iodo]benzene; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 4h;

upstream raw materials:

3-amino-1-(4-fluorophenyl)pyridin-2(1H)-one

4-(2-carbamoylpyridin-4-yloxy)-3-fluorobenzoic acid

Downstream raw materials:

4-(2-aminopyridin-4-yloxy)-3-fluoroN-(1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridin-3-yl)benzamide, trifluoroacetic acid salt

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