tert-butyl (2S,4R)-1-(tert-butoxycarbonyl)-4-(cyanomethyl)pyroglutamate

Base Information

• Chemical Name: tert-butyl (2S,4R)-1-(tert-butoxycarbonyl)-4-(cyanomethyl)pyroglutamate
• CAS No.: 153080-74-1
• Molecular Formula: C₁₆H₂₄N₂O₅
• Molecular Weight: 324.377
• Mol file: 153080-74-1.mol

Synonyms:tert-butyl (2S,4R)-1-(tert-butoxycarbonyl)-4-(cyanomethyl)pyroglutamate

Chemical Property of tert-butyl (2S,4R)-1-(tert-butoxycarbonyl)-4-(cyanomethyl)pyroglutamate

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of tert-butyl (2S,4R)-1-(tert-butoxycarbonyl)-4-(cyanomethyl)pyroglutamate

There total 1 articles about tert-butyl (2S,4R)-1-(tert-butoxycarbonyl)-4-(cyanomethyl)pyroglutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

iodoacetonitrile (624-75-9) + tert-butyl (S)-N-tert-butoxycarbonylpyroglutamate (91229-91-3) → tert-butyl (2S,4S)-1-(tert-butoxycarbonyl)-4-(cyanomethyl)pyroglutamate (153080-73-0) + tert-butyl (2S,4R)-1-(tert-butoxycarbonyl)-4-(cyanomethyl)pyroglutamate (153080-74-1)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; Product distribution; 1.) 1 h, 2.) 2 h;

DOI:10.1016/S0040-4020(01)96272-6

upstream raw materials:

iodoacetonitrile

tert-butyl (S)-N-tert-butoxycarbonylpyroglutamate