4-(5-chloro-thiophen-2-yl)-5-hydroxy-5-methyl-3-(2,4,6-trifluoro-phenyl)-5H-furan-2-one

Base Information

Chemical Name:4-(5-chloro-thiophen-2-yl)-5-hydroxy-5-methyl-3-(2,4,6-trifluoro-phenyl)-5H-furan-2-one
CAS No.:1002757-02-9
Molecular Formula:C₁₅H₈ClF₃O₃S
Molecular Weight:360.741
Hs Code.:

Synonyms:4-(5-chloro-thiophen-2-yl)-5-hydroxy-5-methyl-3-(2,4,6-trifluoro-phenyl)-5H-furan-2-one

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Chemical Property of 4-(5-chloro-thiophen-2-yl)-5-hydroxy-5-methyl-3-(2,4,6-trifluoro-phenyl)-5H-furan-2-one

Chemical Property:

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Technology Process of 4-(5-chloro-thiophen-2-yl)-5-hydroxy-5-methyl-3-(2,4,6-trifluoro-phenyl)-5H-furan-2-one

There total 7 articles about 4-(5-chloro-thiophen-2-yl)-5-hydroxy-5-methyl-3-(2,4,6-trifluoro-phenyl)-5H-furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374964-00-7
C₁₅H₈ClF₃O₂S

: 1002757-02-9
4-(5-chloro-thiophen-2-yl)-5-hydroxy-5-methyl-3-(2,4,6-trifluoro-phenyl)-5H-furan-2-one

Guidance literature:: With air; In acetonitrile; for 3h;
DOI:10.1016/j.bmc.2012.03.035

Reference yield:

: 24065-33-6
5-Chlorothiophene-2-carboxylic acid

: 1002757-02-9
4-(5-chloro-thiophen-2-yl)-5-hydroxy-5-methyl-3-(2,4,6-trifluoro-phenyl)-5H-furan-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / Inert atmosphere; Reflux

2: triethylamine / dichloromethane / 5 - 20 °C / Inert atmosphere

3: tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

4: hydrogen bromide; bromine; acetic acid / 10 - 20 °C / Inert atmosphere

5: triethylamine / acetonitrile / 16 h / 20 °C / Inert atmosphere

6: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 20 - 30 °C / Inert atmosphere

7: air / acetonitrile / 3 h

With oxalyl dichloride; hydrogen bromide; bromine; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; acetonitrile; 6: Aldol condensation;
DOI:10.1016/j.bmc.2012.03.035

Reference yield:

: 32427-82-0
1-(5-chloro-thiophen-2-yl)-propan-1-one

: 1002757-02-9
4-(5-chloro-thiophen-2-yl)-5-hydroxy-5-methyl-3-(2,4,6-trifluoro-phenyl)-5H-furan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen bromide; bromine; acetic acid / 10 - 20 °C / Inert atmosphere

2: triethylamine / acetonitrile / 16 h / 20 °C / Inert atmosphere

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 20 - 30 °C / Inert atmosphere

4: air / acetonitrile / 3 h

With hydrogen bromide; bromine; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In acetonitrile; 3: Aldol condensation;
DOI:10.1016/j.bmc.2012.03.035