(2R)-2-(4-cyclopropanesulfonylphenyl)-3-(tetrahydropyran-4-yl)-N-thiazol-2-ylpropionamide

Base Information

Chemical Name:(2R)-2-(4-cyclopropanesulfonylphenyl)-3-(tetrahydropyran-4-yl)-N-thiazol-2-ylpropionamide
CAS No.:745051-68-7
Molecular Formula:C₂₀H₂₄N₂O₄S₂
Molecular Weight:420.554
Hs Code.:

Synonyms:(2R)-2-(4-cyclopropanesulfonylphenyl)-3-(tetrahydropyran-4-yl)-N-thiazol-2-ylpropionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-2-(4-cyclopropanesulfonylphenyl)-3-(tetrahydropyran-4-yl)-N-thiazol-2-ylpropionamide

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Technology Process of (2R)-2-(4-cyclopropanesulfonylphenyl)-3-(tetrahydropyran-4-yl)-N-thiazol-2-ylpropionamide

There total 2 articles about (2R)-2-(4-cyclopropanesulfonylphenyl)-3-(tetrahydropyran-4-yl)-N-thiazol-2-ylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 96-50-4
2-thiazolylamine

: 745053-49-0,745052-93-1
(R)-2-(4-(cyclopropylsulfonyl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)propanoic acid

: 745051-68-7
(2R)-2-(4-cyclopropanesulfonylphenyl)-3-(tetrahydropyran-4-yl)-N-thiazol-2-ylpropionamide

Guidance literature:: (R)-2-(4-(cyclopropylsulfonyl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)propanoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at -20 ℃;

With 2,3,5-trimethyl-pyridine; In dichloromethane;

2-thiazolylamine; In dichloromethane; at -15 - 20 ℃; for 4h;
DOI:10.1021/jm8003202