(R)-2-(4-Cyclopropanesulfonylphenyl)-3-(tetrahydropyran-4-yl)propionic acid

Base Information

Chemical Name:(R)-2-(4-Cyclopropanesulfonylphenyl)-3-(tetrahydropyran-4-yl)propionic acid
CAS No.:745053-49-0
Molecular Formula:C17H22 O5 S
Molecular Weight:338.425
Hs Code.:2932999099
DSSTox Substance ID:DTXSID50469865
Wikidata:Q82297775
Mol file:745053-49-0.mol

Synonyms:745053-49-0;(R)-2-(4-Cyclopropanesulfonylphenyl)-3-(tetrahydropyran-4-yl)propionic acid;(2R)-2-(4-cyclopropylsulfonylphenyl)-3-(oxan-4-yl)propanoic acid;(R)-2-(4-(Cyclopropylsulfonyl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)propanoic acid;SCHEMBL1107461;DTXSID50469865;IMDSBCGXPMSCCM-MRXNPFEDSA-N;AG-G-96295;(2R)-2-(4-cyclopropanesulfonylphenyl)-3-(tetrahydropyran-4-yl)propionic acid;(R)-2-(4-(Cyclopropylsulfonyl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)propanoicacid;(R)-2-(4-CYCLOPROPANESULFONYLPHENYL)-3-(TETRAHYDROPYRAN-4-YL)PROPIONICACID

Suppliers and Price of (R)-2-(4-Cyclopropanesulfonylphenyl)-3-(tetrahydropyran-4-yl)propionic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(R)-2-(4-(Cyclopropylsulfonyl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)propanoicacid 97%
1g
$ 1760.00

American Custom Chemicals Corporation
(R)-2-(4-CYCLOPROPANESULFONYLPHENYL)-3-(TETRAHYDROPYRAN-4-YL)PROPIONIC ACID 95.00%
1G
$ 1637.21

Total 3 raw suppliers

Chemical Property of (R)-2-(4-Cyclopropanesulfonylphenyl)-3-(tetrahydropyran-4-yl)propionic acid

Chemical Property:

PSA：89.05000
LogP:3.68840
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:338.11879497
Heavy Atom Count:23
Complexity:506

Purity/Quality:

98% ^*data from raw suppliers

(R)-2-(4-(Cyclopropylsulfonyl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)propanoicacid 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC1S(=O)(=O)C2=CC=C(C=C2)C(CC3CCOCC3)C(=O)O
Isomeric SMILES:C1CC1S(=O)(=O)C2=CC=C(C=C2)[C@@H](CC3CCOCC3)C(=O)O

Technology Process of (R)-2-(4-Cyclopropanesulfonylphenyl)-3-(tetrahydropyran-4-yl)propionic acid

There total 23 articles about (R)-2-(4-Cyclopropanesulfonylphenyl)-3-(tetrahydropyran-4-yl)propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.8%

: (3R)-1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-yl (2R)-2-[4-(cyclopropylsulfonyl)phenyl]-3-(tetrahydro-2H-pyran-4-yl)propanoate

: 745053-49-0,745052-93-1
(R)-2-(4-(cyclopropylsulfonyl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)propanoic acid

Guidance literature:: (3R)-1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-yl (2R)-2-[4-(cyclopropylsulfonyl)phenyl]-3-(tetrahydro-2H-pyran-4-yl)propanoate; With lithium hydroxide monohydrate; dihydrogen peroxide; In methanol; water; at -10 ℃; for 1h;

With sodium sulfite; In methanol; water; at -10 - 20 ℃;
DOI:10.1002/ejoc.201301383

Reference yield: 91.0%

: 1001327-35-0
C₁₇H₂₂O₃S

: 745053-49-0,745052-93-1
(R)-2-(4-(cyclopropylsulfonyl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)propanoic acid

Guidance literature:: With oxone(R); In water; isopropyl alcohol; at 20 ℃; for 18h;

Reference yield: 86.0%

: 745052-98-6
(E)-2-(4-(cyclopropylsulfonyl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)acrylic acid

: 745053-49-0,745052-93-1
(R)-2-(4-(cyclopropylsulfonyl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)propanoic acid

: 745052-93-1
(S)-2-(4-(cyclopropylsulfonyl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)propanoic acid

Guidance literature:: With bis(norbornadiene)rhodium(l)tetrafluoroborate; (S_P,S′_P)-1,1′-bis[bis(4-methoxy-3,5-dimethylphenyl)phosphino]-2,2′-bis[(R)-α-(dimethylamino)benzyl]ferrocene; hydrogen; triethylamine; In methanol; at 20 ℃; for 4h; under 4380.18 Torr; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Autoclave;
DOI:10.1021/op300053a