11-benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-4-(tert-butyl-diphenyl-silanyloxymethyl)-undec-2-en-7-yn-6-ol

Base Information

• Chemical Name: 11-benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-4-(tert-butyl-diphenyl-silanyloxymethyl)-undec-2-en-7-yn-6-ol
• CAS No.: 896110-65-9
• Molecular Formula: C₅₁H₆₂O₄Si₂
• Molecular Weight: 795.222

Synonyms:11-benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-4-(tert-butyl-diphenyl-silanyloxymethyl)-undec-2-en-7-yn-6-ol

Chemical Property of 11-benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-4-(tert-butyl-diphenyl-silanyloxymethyl)-undec-2-en-7-yn-6-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 11-benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-4-(tert-butyl-diphenyl-silanyloxymethyl)-undec-2-en-7-yn-6-ol

There total 12 articles about 11-benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-4-(tert-butyl-diphenyl-silanyloxymethyl)-undec-2-en-7-yn-6-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(E)-(S)-6-(tert-butyldiphenylsilyloxy)-3-(tert-butyldiphenylsilyloxymethyl)hex-4-enal (896110-43-3) + 5-benzyloxy-1-pentyne (57618-47-0) → 11-benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-4-(tert-butyl-diphenyl-silanyloxymethyl)-undec-2-en-7-yn-6-ol (896110-65-9)

Guidance literature:

5-benzyloxy-1-pentyne; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - -40 ℃;

(E)-(S)-6-(tert-butyldiphenylsilyloxy)-3-(tert-butyldiphenylsilyloxymethyl)hex-4-enal; In tetrahydrofuran; hexane; at -78 - -40 ℃; for 1h;

DOI:10.1016/j.tet.2005.11.096

Reference yield:

(E)-(R)-5-(tert-butyldiphenylsilyloxy)pent-3-ene-1,2-diol (896110-40-0) → 11-benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-4-(tert-butyl-diphenyl-silanyloxymethyl)-undec-2-en-7-yn-6-ol (896110-65-9)

Guidance literature:

Multi-step reaction with 7 steps

1.1: 82 percent / imidazole / tetrahydrofuran / 7 h / -15 °C

2.1: 92 percent / pyridine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 0 - 20 °C

3.1: tert-butyldimethylsilyl chloride / tetrahydrofuran

3.2: potassium hexamethyldisilazide / tetrahydrofuran / -78 - 20 °C

3.3: 100 percent / LiOH / tetrahydrofuran; H₂O / 1 h / 0 °C

4.1: 73 percent / K₂CO₃ / dimethylformamide / 1.5 h / 20 °C

5.1: 95 percent / DIBAL-H / tetrahydrofuran; hexane / -78 - 20 °C

6.1: 100 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / -78 - 0 °C

7.1: n-BuLi / tetrahydrofuran; hexane / -78 - -40 °C

7.2: 87 percent / tetrahydrofuran; hexane / 1 h / -78 - -40 °C

With pyridine; 1H-imidazole; dmap; n-butyllithium; oxalyl dichloride; diisobutylaluminium hydride; potassium carbonate; tert-butyldimethylsilyl chloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; 6.1: Swern oxidation;

DOI:10.1016/j.tet.2005.11.096

Reference yield:

(E)-(R)-1,5-Bis-(tert-butyl-diphenyl-silanyloxy)-pent-3-en-2-ol (896110-69-3) → 11-benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-4-(tert-butyl-diphenyl-silanyloxymethyl)-undec-2-en-7-yn-6-ol (896110-65-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 92 percent / pyridine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 0 - 20 °C

2.1: tert-butyldimethylsilyl chloride / tetrahydrofuran

2.2: potassium hexamethyldisilazide / tetrahydrofuran / -78 - 20 °C

2.3: 100 percent / LiOH / tetrahydrofuran; H₂O / 1 h / 0 °C

3.1: 73 percent / K₂CO₃ / dimethylformamide / 1.5 h / 20 °C

4.1: 95 percent / DIBAL-H / tetrahydrofuran; hexane / -78 - 20 °C

5.1: 100 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / -78 - 0 °C

6.1: n-BuLi / tetrahydrofuran; hexane / -78 - -40 °C

6.2: 87 percent / tetrahydrofuran; hexane / 1 h / -78 - -40 °C

With pyridine; dmap; n-butyllithium; oxalyl dichloride; diisobutylaluminium hydride; potassium carbonate; tert-butyldimethylsilyl chloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; 5.1: Swern oxidation;

DOI:10.1016/j.tet.2005.11.096

upstream raw materials:

(E)-(S)-6-(tert-butyldiphenylsilyloxy)-3-(tert-butyldiphenylsilyloxymethyl)hex-4-enal

5-benzyloxy-1-pentyne

(E)-(R)-5-(tert-butyldiphenylsilyloxy)pent-3-ene-1,2-diol

(E)-(R)-1,5-Bis-(tert-butyl-diphenyl-silanyloxy)-pent-3-en-2-ol

Downstream raw materials:

[(E)-(4S,6R)-11-benzyloxy-4-(tert-butyldiphenylsilyloxymethyl)-(6-methoxymethoxy)undec-2-en-7-ynyl]oxy-tert-butyldiphenylsilane

11-benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-4-(tert-butyl-diphenyl-silanyloxymethyl)-undec-2-en-7-yn-6-ol

{(1S,4R)-3-[4-Benzyloxy-but-(Z)-ylidene]-4-methoxymethoxy-2-methylene-cyclopentylmethoxy}-tert-butyl-diphenyl-silane

((2S,4R)-9'-benzyloxy-4'-methoxymethoxy-2'-vinyl-non-5'-ynyloxy)-tert-butyldiphenylsilane

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 896110-65-9 11-benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-4-(tert-butyl-diphenyl-silanyloxymethyl)-undec-2-en-7-yn-6-ol

Send

Send

Metric Ton KG G Pound L ML

Send

Send