4-methyl-N-[(trifluoromethyl)sulfanyl]benzene-1-sulfonamide

Base Information

• Chemical Name: 4-methyl-N-[(trifluoromethyl)sulfanyl]benzene-1-sulfonamide
• CAS No.: 1045822-03-4
• Molecular Formula: C₈H₈F₃NO₂S₂
• Molecular Weight: 271.284
• Mol file: 1045822-03-4.mol

Synonyms:4-methyl-N-[(trifluoromethyl)sulfanyl]benzene-1-sulfonamide

Chemical Property of 4-methyl-N-[(trifluoromethyl)sulfanyl]benzene-1-sulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-methyl-N-[(trifluoromethyl)sulfanyl]benzene-1-sulfonamide

There total 3 articles about 4-methyl-N-[(trifluoromethyl)sulfanyl]benzene-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-[(diethylamino)(trifluoromethyl)-λ4-sulfanylidene]-4-methylbenzenesulfonamide → 4-methyl-N-[(trifluoromethyl)sulfanyl]benzene-1-sulfonamide (1045822-03-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 50 ℃; for 24h;

DOI:10.1021/jo8018544

Reference yield: 95.0%

N-((diethylamino)(trifluoromethyl)sulfanylidene)-4-methylbenzenesulfonamide → 4-methyl-N-[(trifluoromethyl)sulfanyl]benzene-1-sulfonamide (1045822-03-4)

Guidance literature:

With sulfuric acid; In dichloromethane; Reflux; Schlenk technique;

DOI:10.1002/ejoc.201800451

Reference yield:

toluene-4-sulfonamide (70-55-3) → 4-methyl-N-[(trifluoromethyl)sulfanyl]benzene-1-sulfonamide (1045822-03-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / -60 °C / Schlenk technique; Inert atmosphere

1.2: -60 - 20 °C / Schlenk technique; Inert atmosphere

2.1: sulfuric acid / dichloromethane / Reflux; Schlenk technique

With sulfuric acid; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1002/ejoc.201800451

upstream raw materials:

toluene-4-sulfonamide

Downstream raw materials:

2-(2-((trifluoromethyl)thio)phenyl)pyridine

2-(4-methyl-2-((trifluoromethyl)thio)phenyl)pyridine

2-(4-methoxy-2-((trifluoromethyl)thio)phenyl)pyridine

2-(2-Bromophenyl)pyridine