3-(4-methoxyphenyl)-1-[4-(trifluoromethyl)phenyl]prop-2-yn-1-one

Base Information

• Chemical Name: 3-(4-methoxyphenyl)-1-[4-(trifluoromethyl)phenyl]prop-2-yn-1-one
• CAS No.: 1207385-17-8
• Molecular Formula: C₁₇H₁₁F₃O₂
• Molecular Weight: 304.268
• Mol file: 1207385-17-8.mol

Synonyms:3-(4-methoxyphenyl)-1-[4-(trifluoromethyl)phenyl]prop-2-yn-1-one

Chemical Property of 3-(4-methoxyphenyl)-1-[4-(trifluoromethyl)phenyl]prop-2-yn-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-methoxyphenyl)-1-[4-(trifluoromethyl)phenyl]prop-2-yn-1-one

There total 3 articles about 3-(4-methoxyphenyl)-1-[4-(trifluoromethyl)phenyl]prop-2-yn-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-trifluoromethyl-phenyl acetyl chloride (329-15-7) + 4-methoxyphenylacetylen (768-60-5) → 3-(4-methoxyphenyl)-1-[4-(trifluoromethyl)phenyl]prop-2-yn-1-one (1207385-17-8)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine;

DOI:10.1016/j.dyepig.2019.107646

Reference yield: 75.0%

2-[((4-methoxyphenyl)ethynyl)]-4,4,5,5-tetramethyl[1,3,2]dioxaborolane (872356-95-1) + 4-trifluoromethyl-phenyl acetyl chloride (329-15-7) → 3-(4-methoxyphenyl)-1-[4-(trifluoromethyl)phenyl]prop-2-yn-1-one (1207385-17-8)

Guidance literature:

With copper(l) chloride; In DMI; at 120 ℃; for 0.5h; Inert atmosphere;

DOI:10.1016/j.tetlet.2009.11.001

Reference yield: 66.0%

para-iodoanisole (696-62-8) + 4-trifluoromethyl-phenyl acetyl chloride (329-15-7) + acetylenemagnesium bromide (4301-14-8) → 3-(4-methoxyphenyl)-1-[4-(trifluoromethyl)phenyl]prop-2-yn-1-one (1207385-17-8)

Guidance literature:

para-iodoanisole; acetylenemagnesium bromide; With bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; at 45 ℃; for 0.75h; Schlenk technique; Inert atmosphere;

4-trifluoromethyl-phenyl acetyl chloride; With copper(l) iodide; triethylamine hydrochloride; triethylamine; In tetrahydrofuran; at 45 ℃; for 1h; Schlenk technique; Inert atmosphere;

DOI:10.3762/bjoc.15.262

upstream raw materials:

2-[((4-methoxyphenyl)ethynyl)]-4,4,5,5-tetramethyl[1,3,2]dioxaborolane

4-trifluoromethyl-phenyl acetyl chloride

4-methoxyphenylacetylen

para-iodoanisole