N-methyl-N-[isopropylamino(4-methoxyphenyl)-phosphinothioyloxy] 4-chlorobenzamide

Base Information

Chemical Name:N-methyl-N-[isopropylamino(4-methoxyphenyl)-phosphinothioyloxy] 4-chlorobenzamide
CAS No.:1144028-91-0
Molecular Formula:C₁₈H₂₂ClN₂O₃PS
Molecular Weight:412.877
Hs Code.:

Synonyms:N-methyl-N-[isopropylamino(4-methoxyphenyl)-phosphinothioyloxy] 4-chlorobenzamide

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Chemical Property of N-methyl-N-[isopropylamino(4-methoxyphenyl)-phosphinothioyloxy] 4-chlorobenzamide

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Technology Process of N-methyl-N-[isopropylamino(4-methoxyphenyl)-phosphinothioyloxy] 4-chlorobenzamide

There total 3 articles about N-methyl-N-[isopropylamino(4-methoxyphenyl)-phosphinothioyloxy] 4-chlorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1144028-81-8
bis[isopropylamino(4-methoxyphenyl)phosphinothioyl]disulfane

: 1613-83-8
N-methyl-N-(4-chlorobenzoyl)hydroxylamine

: 1144028-91-0
N-methyl-N-[isopropylamino(4-methoxyphenyl)-phosphinothioyloxy] 4-chlorobenzamide

Guidance literature:: N-methyl-N-(4-chlorobenzoyl)hydroxylamine; With sodium hydride; In tetrahydrofuran; for 1.5h; Inert atmosphere; Reflux;

bis[isopropylamino(4-methoxyphenyl)phosphinothioyl]disulfane; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1007/s11224-020-01719-1

Reference yield: 91.0%

: 1144028-81-8
bis[isopropylamino(4-methoxyphenyl)phosphinothioyl]disulfane

: 123381-62-4
N-methyl-4-chlorobenzohydroxamic acid sodium salt

: 1144028-91-0
N-methyl-N-[isopropylamino(4-methoxyphenyl)-phosphinothioyloxy] 4-chlorobenzamide

: 1144028-92-1
C₁₀H₁₅NOPS₂^(1-)*Na⁽¹⁺⁾

Guidance literature:: N-methyl-4-chlorobenzohydroxamic acid sodium salt; With sodium hydride; In tetrahydrofuran; for 1.5h; Heating;

bis[isopropylamino(4-methoxyphenyl)phosphinothioyl]disulfane; In tetrahydrofuran; at 20 ℃; for 0.333333h; Further stages.;
DOI:10.1002/hc.20423

Reference yield:

: 122-01-0
4-chloro-benzoyl chloride

: 1144028-91-0
N-methyl-N-[isopropylamino(4-methoxyphenyl)-phosphinothioyloxy] 4-chlorobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran / 1.5 h / Inert atmosphere; Reflux

2.2: 1 h / 20 °C / Inert atmosphere

With sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1007/s11224-020-01719-1