Ethanone, 1-imidazo[5,1-b]thiazol-7-yl- (9CI)

Base Information

• Chemical Name: Ethanone, 1-imidazo[5,1-b]thiazol-7-yl- (9CI)
• CAS No.: 258838-72-1
• Molecular Formula: C₇H₆N₂OS
• Molecular Weight: 166.203
• Mol file: 258838-72-1.mol

Synonyms:7-Acetylimidazo[5,1-b]thiazole

Chemical Property of Ethanone, 1-imidazo[5,1-b]thiazol-7-yl- (9CI)

Chemical Property:

• PSA: 62.61000
• LogP: 1.59840

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanone, 1-imidazo[5,1-b]thiazol-7-yl- (9CI)

There total 1 articles about Ethanone, 1-imidazo[5,1-b]thiazol-7-yl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

imidazo[5,1-b]thiazole (251-89-8) → 7-acetylimidazo[5,1-b]thiazole (258838-72-1)

Guidance literature:

Reference yield:

7-acetylimidazo[5,1-b]thiazole (258838-72-1) → 4-Nitrobenzyl(1S,5R,6S)-6-((1R)-1-hydroxyethyl)-2-(7-methanesulfonylaminoacetylimidazo-[5,1-b]thiazol-2-yl)-1-methyl-1-carbapen-2-em-3-carboxylate (258840-51-6)

Guidance literature:

Multi-step reaction with 4 steps

1: N-Bromosuccinimide; chloro-trimethyl-silane / tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; ethyl acetate; N,N-dimethyl-formamide

2: hydrogenchloride; sodium hydroxide; N-ethyl-N,N-diisopropylamine / Pd-C / tetrahydrofuran; dichloromethane; water; hydrogen

3: n-butyllithium; ammonium chloride / tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane

With hydrogenchloride; sodium hydroxide; N-Bromosuccinimide; n-butyllithium; chloro-trimethyl-silane; ammonium chloride; N-ethyl-N,N-diisopropylamine; Pd-C; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; water; hydrogen; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

7-acetylimidazo[5,1-b]thiazole (258838-72-1) → 4-nitrobenzyl(1S,5R,6S)-2-(7-acetylaminoacetylimidazo[5,1-b]thiazol-2-yl)-6-((1R)-1-hydroxyethyl)-1-methyl-1-carbapen-2-em-3-carboxylate (258840-26-5)

Guidance literature:

Multi-step reaction with 4 steps

1: N-Bromosuccinimide; chloro-trimethyl-silane / tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; ethyl acetate; N,N-dimethyl-formamide

2: pyridine; hydrogenchloride; acetic anhydride; potassium carbonate / Pd-C / tetrahydrofuran; methanol; dichloromethane; hydrogen; N,N-dimethyl-formamide

3: ammonium chloride / tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide

With pyridine; hydrogenchloride; N-Bromosuccinimide; chloro-trimethyl-silane; ammonium chloride; acetic anhydride; potassium carbonate; Pd-C; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; hydrogen; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

imidazo[5,1-b]thiazole

Downstream raw materials:

7-(4-Nitrobenzyloxycarbonylamino)acetyl-imidazo[5,1-b]thiazole

7-[2-(4-Nitrobenzyloxycarbonyl)-aminoethanesulfonylamino]acetylimidazo[5,1-b]-thiazole

7-(4-nitrobenzyloxycarbonylamino)acetyl-2-(tri-n-butylstannyl)imidazo[5,1-b]thiazole

7-[2-(4-nitrobenzyloxycarbonyl)aminoethane-sulfonylamino]acetyl-2-(tri-n-butylstannyl)-imidazo[5,1-b]thiazole