ethyl 1-benzyl-7-chloro-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate

Base Information

Chemical Name:ethyl 1-benzyl-7-chloro-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate
CAS No.:1429014-07-2
Molecular Formula:C₁₉H₁₆ClNO₄
Molecular Weight:357.793
Hs Code.:

Synonyms:ethyl 1-benzyl-7-chloro-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate

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Chemical Property of ethyl 1-benzyl-7-chloro-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate

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Technology Process of ethyl 1-benzyl-7-chloro-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate

There total 4 articles about ethyl 1-benzyl-7-chloro-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 35709-36-5
4-chloro-N-benzylisatoic anhydride

: 105-53-3
diethyl malonate

: 1429014-07-2
ethyl 1-benzyl-7-chloro-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate

Guidance literature:: diethyl malonate; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

4-chloro-N-benzylisatoic anhydride; In N,N-dimethyl-formamide; at 50 ℃; for 5h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.7b00395

Reference yield: 94.0%

: 1429014-07-2
ethyl 1-benzyl-7-chloro-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

In N,N-dimethyl-formamide;

Reference yield:

: 40928-13-0
4-chloroisatoic anhydride

: 1429014-07-2
ethyl 1-benzyl-7-chloro-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

2.2: 5 h / 50 °C / Inert atmosphere

With sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.7b00395