2,3-Pyridinediamine, 5-bromo-N,N,N,N-tetrakis(4-methoxyphenyl)methyl-

Base Information

• Chemical Name: 2,3-Pyridinediamine, 5-bromo-N,N,N,N-tetrakis(4-methoxyphenyl)methyl-
• CAS No.: 258834-82-1
• Molecular Formula: C37H38 Br N3 O4
• Molecular Weight: 668.62
• Mol file: 258834-82-1.mol

Synonyms:2,3-Pyridinediamine,5-bromo-N,N,N',N'-tetrakis[(4-methoxyphenyl)methyl]- (9CI)

Chemical Property of 2,3-Pyridinediamine, 5-bromo-N,N,N,N-tetrakis(4-methoxyphenyl)methyl-

Chemical Property:

• PSA: 56.29000
• LogP: 8.29210

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-Pyridinediamine, 5-bromo-N,N,N,N-tetrakis(4-methoxyphenyl)methyl-

There total 2 articles about 2,3-Pyridinediamine, 5-bromo-N,N,N,N-tetrakis(4-methoxyphenyl)methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-pyridine-2,3-diamine (38875-53-5) + p-methoxybenzyl chloride (824-94-2) → 5-bromo-2,3-bis[di-(4-methoxybenzyl)amino]pyridine (258834-82-1)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 384h;

DOI:10.1016/S0968-0896(99)00210-2

Reference yield:

5-bromo-3-nitro-pyridin-2-ylamine (6945-68-2) → 5-bromo-2,3-bis[di-(4-methoxybenzyl)amino]pyridine (258834-82-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.94 g / FeCl₃; activated charcoal; hydrazine hydrate / methanol / 3 h / Heating

2: 3.52 g / NaH / dimethylformamide / 384 h / 20 °C

With iron(III) chloride; sodium hydride; pyrographite; hydrazine hydrate; In methanol; N,N-dimethyl-formamide; 1: Reduction / 2: Substitution;

DOI:10.1016/S0968-0896(99)00210-2

Reference yield: 46.0%

(3aR,4R,6aS)-4-(((tert-butyldimethylsilyl)oxy)methyl)-2,2-dimethyl-4,6a-dihydro-3aH-[1,3]dioxolo[4,5-c]pyrrole (153172-33-9) + 5-bromo-2,3-bis[di-(4-methoxybenzyl)amino]pyridine (258834-82-1) → (1S)-5-O-tert-butyldimethylsilyl-1,4-dideoxy-1,4-imino-2,3-O-isopropylidene-1-{2,3-bis[di-(4-methoxybenzyl)amino]-5-pyridyl}-D-ribitol (258834-83-2)

Guidance literature:

5-bromo-2,3-bis[di-(4-methoxybenzyl)amino]pyridine; With n-butyllithium; In diethyl ether; at -40 ℃; for 0.5h;

(3aR,4R,6aS)-4-(((tert-butyldimethylsilyl)oxy)methyl)-2,2-dimethyl-4,6a-dihydro-3aH-[1,3]dioxolo[4,5-c]pyrrole; at -78 ℃; for 0.5h;

DOI:10.1016/S0968-0896(99)00210-2

upstream raw materials:

5-bromo-pyridine-2,3-diamine

p-methoxybenzyl chloride

5-bromo-3-nitro-pyridin-2-ylamine

Downstream raw materials:

(1S)-5-O-tert-butyldimethylsilyl-1,4-dideoxy-1,4-imino-2,3-O-isopropylidene-1-{2,3-bis[di-(4-methoxybenzyl)amino]-5-pyridyl}-D-ribitol