[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]methyl trifluoroacetate

Base Information

Chemical Name:[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]methyl trifluoroacetate
CAS No.:1391833-13-8
Molecular Formula:C₂₁H₁₅F₄NO₂
Molecular Weight:389.349
Hs Code.:

Synonyms:[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]methyl trifluoroacetate

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Chemical Property of [2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]methyl trifluoroacetate

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Technology Process of [2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]methyl trifluoroacetate

There total 2 articles about [2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]methyl trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 121660-11-5
2-cyclopropyl-4-(4-fluorophenyl)-3-(hydroxymethyl)quinoline

: 407-25-0
trifluoroacetic anhydride

: 1391833-13-8
[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]methyl trifluoroacetate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1055/s-0031-1290916

Reference yield:

: 154057-56-4
3-(bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)-quinoline

: 1391833-13-8
[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]methyl trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: water; sodium hydrogencarbonate / acetonitrile / 64 h / Reflux

2: triethylamine / tetrahydrofuran / 2 h / 20 °C

With water; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; acetonitrile;
DOI:10.1055/s-0031-1290916