2-chloro-N-(2,4-difluorophenyl)-4-iodonicotinamide

Base Information

• Chemical Name: 2-chloro-N-(2,4-difluorophenyl)-4-iodonicotinamide
• CAS No.: 931105-30-5
• Molecular Formula: C₁₂H₆ClF₂IN₂O
• Molecular Weight: 394.547
• Mol file: 931105-30-5.mol

Synonyms:2-chloro-N-(2,4-difluorophenyl)-4-iodonicotinamide

Chemical Property of 2-chloro-N-(2,4-difluorophenyl)-4-iodonicotinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-N-(2,4-difluorophenyl)-4-iodonicotinamide

There total 1 articles about 2-chloro-N-(2,4-difluorophenyl)-4-iodonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

2,4-difluorophenylamine (367-25-9,76563-56-9) + 2-chloro-4-iodo-3-pyridinecarboxylic acid (544671-78-5) → 2-chloro-N-(2,4-difluorophenyl)-4-iodonicotinamide (931105-30-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; for 63h;

Reference yield: 65.0%

2-chloro-N-(2,4-difluorophenyl)-4-iodonicotinamide (931105-30-5) + sodium methylate (124-41-4) → 2-chloro-N-(2,4-difluorophenyl)-4-methoxynicotinamide (931105-31-6)

Guidance literature:

In methanol; at 60 ℃; for 12h;

upstream raw materials:

2,4-difluorophenylamine

2-chloro-4-iodo-3-pyridinecarboxylic acid

Downstream raw materials:

2-chloro-N-(2,4-difluorophenyl)-4-methoxynicotinamide