3-Fluorothiophene-2-carbohydrazide

Base Information

• Chemical Name: 3-Fluorothiophene-2-carbohydrazide
• CAS No.: 258522-49-5
• Molecular Formula: C₅H₅FN₂OS
• Molecular Weight: 160.172
• DSSTox Substance ID: DTXSID20579086
• Nikkaji Number: J1.234.753G
• Wikidata: Q82469492
• Mol file: 258522-49-5.mol

Synonyms:3-fluorothiophene-2-carbohydrazide;258522-49-5;DTXSID20579086

Chemical Property of 3-Fluorothiophene-2-carbohydrazide

Chemical Property:

• PSA: 86.85000
• LogP: 1.76580
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 160.01066212
• Heavy Atom Count: 10
• Complexity: 144

Purity/Quality:

99%+ ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CSC(=C1F)C(=O)NN

Technology Process of 3-Fluorothiophene-2-carbohydrazide

There total 3 articles about 3-Fluorothiophene-2-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

methyl 3-fluorothiophene-2-carboxylate (100421-52-1) → 3-fluorothiophene-2-carboxylic hydrazide (258522-49-5)

Guidance literature:

With hydrazine hydrate; In ethanol; for 0.25h; Heating;

DOI:10.1002/jhet.5570360522

Reference yield:

2-(methoxycarbonyl)thiophene-3-diazonium tetrafluoroborate → 3-fluorothiophene-2-carboxylic hydrazide (258522-49-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 32 percent / 160 °C / 1 - 1.5 Torr

2: 78 percent / aq. hydrazine hydrate / ethanol / 0.25 h / Heating

With hydrazine hydrate; In ethanol; 1: Decomposition / 2: Substitution;

DOI:10.1002/jhet.5570360522

Reference yield:

2-(methoxycarbonyl)thiophene-3-diazonium hexafluorophosphate → 3-fluorothiophene-2-carboxylic hydrazide (258522-49-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 30 percent / 160 °C / 1 - 1.5 Torr

2: 78 percent / aq. hydrazine hydrate / ethanol / 0.25 h / Heating

With hydrazine hydrate; In ethanol; 1: Decomposition / 2: Substitution;

DOI:10.1002/jhet.5570360522

upstream raw materials:

methyl 3-fluorothiophene-2-carboxylate