100421-52-1Relevant articles and documents
A facile and improved synthesis of 3-fluorothiophene
Pomerantz, Martin,Turkman, Nashaat
, p. 2333 - 2336 (2008)
A new efficient and convenient route to 3-fluorothiophene in four steps and 49% overall yield is reported. The fluorine atom was successfully introduced into the thiophene ring in 67% yield using the Schiemann reaction on 2-methoxycarbonylthiophene-3-diazonium tetrafluoroborate. The product, methyl 3-fluorothiophene-2-carboxylate was saponified and the 3-fluorothiophene-2- carboxylic acid was decarboxylated to afford 3-fluorothiophene in 93% yield. Georg Thieme Verlag Stuttgart.
FACTOR XIa INHIBITORS
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Page/Page column 54, (2016/11/02)
The present invention provides a compound of Formula (I); and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
Ring fluorinated thiophenes: Applications to liquid crystal synthesis
Kiryanov, Andre A.,Seed, Alexander J.,Sampson, Paul
, p. 8797 - 8800 (2007/10/03)
Ring fluorinated thiophenes were synthesized via a Balz-Schiemann fluorination approach and were successfully employed in the synthesis of liquid crystals using regioselective electrophilic bromination and regioselective Suzuki coupling chemistry.