4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluoro-phenoxy)-N-(methyl-d₃)picolinamide hydrochloride

Base Information

• Chemical Name: 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluoro-phenoxy)-N-(methyl-d₃)picolinamide hydrochloride
• CAS No.: 1333488-98-4
• Molecular Formula: C₂₁H₁₅ClF₄N₄O₃*ClH
• Molecular Weight: 522.259

Synonyms:4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluoro-phenoxy)-N-(methyl-d₃)picolinamide hydrochloride

Chemical Property of 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluoro-phenoxy)-N-(methyl-d₃)picolinamide hydrochloride

Chemical Property:

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Technology Process of 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluoro-phenoxy)-N-(methyl-d₃)picolinamide hydrochloride

There total 18 articles about 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluoro-phenoxy)-N-(methyl-d₃)picolinamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)-3-fluorophenoxy)-2-(N-1',1',1'-trideuteromethyl)pyridine amide (1255386-16-3) → 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluoro-phenoxy)-N-(methyl-d3)picolinamide hydrochloride (1333488-98-4)

Guidance literature:

With hydrogenchloride; In ethanol; water; for 0.00833333h; Reflux;

Reference yield:

4-chloropicolinic acid (5470-22-4) → 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluoro-phenoxy)-N-(methyl-d3)picolinamide hydrochloride (1333488-98-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

2.1: potassium tert-butylate / N,N-dimethyl acetamide / 0.33 h / 0 - 20 °C

2.2: 100 °C

3.1: hydrogenchloride / ethanol; water / 0.01 h / Reflux

With hydrogenchloride; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; HATU; In ethanol; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide;

Reference yield:

4-Chloro-pyridine-2-carboxylic acid methyl ester (24484-93-3) → 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluoro-phenoxy)-N-(methyl-d3)picolinamide hydrochloride (1333488-98-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / tetrahydrofuran / 20 h / 20 °C

2.1: potassium tert-butylate / N,N-dimethyl acetamide / 0.33 h / 0 - 20 °C

2.2: 100 °C

3.1: hydrogenchloride / ethanol; water / 0.01 h / Reflux

With hydrogenchloride; potassium tert-butylate; potassium carbonate; In tetrahydrofuran; ethanol; N,N-dimethyl acetamide; water;

upstream raw materials:

4-chloro-3-trifluoromethyl-aniline

4-Chloro-pyridine-2-carboxylic acid methyl ester

4-chloropicolinic acid

4-amino-3-fluorophenol

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