1255386-16-3

Upstream product

• 1187945-05-6 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy) picolinic acid 
• 1187945-02-3 tert-butyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinate 
• 1257864-28-0 4-(4-amino-3-fluorophenoxy)-N-(methyl-d₃)picolinamide 
• 871555-75-8 (4-chloro-3-trifluoromethylphenyl)carbamic acid phenyl ester 
• 1333390-56-9 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-hydroxyphenyl)urea 
• 1189858-48-7 4-chloropyridinyl-2-(N-1',1',1'-trideuteromethylcarboxamide) 
• 1020173-15-2 tert-butyl 4-(4-amino-3-fluorophenoxy)picolinate 
• 220000-86-2 tert-butyl 4-chloropyridine-2-carboxylate 
• 327-78-6 4-chloro-3-(trifluoromethyl)phenyl isocyanate 
• 399-95-1 4-amino-3-fluorophenol 
• 5470-22-4 4-chloropicolinic acid 
• 1333489-02-3 methyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinate 
• 7436-22-8 methyl-d3-amine hydrochloride 
• 24484-93-3 4-Chloro-pyridine-2-carboxylic acid methyl ester 

Downstream Products

• 1333390-47-8 C₂₁H₁₂⁽²⁾H₃ClF₄N₄O₃*CH₄O₃S 
• 1333489-03-4 C₂₁H₁₂⁽²⁾H₃ClF₄N₄O₄ 
• 1333488-98-4 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluoro-phenoxy)-N-(methyl-d₃)picolinamide hydrochloride 

Relevant academic research and scientific papers

Preparation deuterated diphenylurea (by machine translation)

The invention relates to a method for preparing deuterated diphenyl urea. Specifically, the invention provides an intermediate N-(1, 1, 1-3 deuterated methyl) benzo succinimide which can be used for preparing a deuterated diphenyl urea compound and an application of the intermediate in the preparation of the deuterated diphenyl urea compound. The method can be used for conveniently preparing the intermediate with the high purity and various deuterated diphenyl urea compounds in high efficiency.

PREPARATION METHOD OF FLUORO-SUBSTITUTED DEUTERATED DIPHENYLUREA

A fluoro-substituted deuterated diphenylurea compound, especially 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-2-(N-(methyl-d3))picolinamide, preparing method and use for treating or preventing tumor and relative diseases thereof.

METHOD FOR PREPARING DEUTERATED DIPHENYLUREA

Disclosed are an intermediate compound of N-(1,1,1-trideuterated methyl)phthalimide, and its use in the preparation of deuterated diphenylurea derivative.

METHOD FOR PREPARING DEUTERATED DIPHENYLUREA

Disclosed are an intermediate compound of N-(1,1,1-trideuterated methyl)phthalimide, and its use in the preparation of deuterated diphenylurea derivative.

UREA DERIVATIVES AS KINASE INHIBITORS

The present invention is directed to novel ureas, their derivatives, pharmaceutically acceptable salts, solvates and hydrates thereof which are useful for the treatment of protein kinases mediated diseases and conditions. The compounds of this invention have a general Formula (I) wherein R, R1 to R10 are defined herein.