5-(11-fluoro-6-methyl-5,6-dihydropyrido[3',2':4,5]pyrimido[1,6-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Base Information

Chemical Name:5-(11-fluoro-6-methyl-5,6-dihydropyrido[3',2':4,5]pyrimido[1,6-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide
CAS No.:1621887-02-2
Molecular Formula:C₃₃H₂₇F₂N₅O₄S
Molecular Weight:627.671
Hs Code.:

5-(11-fluoro-6-methyl-5,6-dihydropyrido[3',2':4,5]pyrimido[1,6-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Synonyms:5-(11-fluoro-6-methyl-5,6-dihydropyrido[3',2':4,5]pyrimido[1,6-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

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Chemical Property of 5-(11-fluoro-6-methyl-5,6-dihydropyrido[3',2':4,5]pyrimido[1,6-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

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Technology Process of 5-(11-fluoro-6-methyl-5,6-dihydropyrido[3',2':4,5]pyrimido[1,6-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

There total 10 articles about 5-(11-fluoro-6-methyl-5,6-dihydropyrido[3',2':4,5]pyrimido[1,6-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1621887-64-6
5-(11-fluoro-6-methylpyrido[3',2':4,5]pyrimido[1,6-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

: 1621887-02-2
5-(11-fluoro-6-methyl-5,6-dihydropyrido[3',2':4,5]pyrimido[1,6-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 25 ℃; for 2h;

Reference yield:

: 1333340-17-2
2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide

: 1621888-64-9
2-chloro-11-fluoro-6-methyl-5,6-dihydropyrido[3',2':4,5]pyrimido[1,6-a]indol-6-amine

: 1621887-02-2
5-(11-fluoro-6-methyl-5,6-dihydropyrido[3',2':4,5]pyrimido[1,6-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate; XPhos; In 1,4-dioxane; water; at 70 ℃; for 16h; Inert atmosphere;

Reference yield:

: 400777-06-2
6-chloro-2-iodopyridin-3-amine

: 1621887-02-2
5-(11-fluoro-6-methyl-5,6-dihydropyrido[3',2':4,5]pyrimido[1,6-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; caesium carbonate / water; 1,4-dioxane / 70 °C / Inert atmosphere

2: 2 h / 0 - 20 °C

3: sodium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / water; 1,4-dioxane / 16 h / 70 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; sodium carbonate; caesium carbonate; XPhos; In 1,4-dioxane; water; 1: |Suzuki Coupling / 3: |Suzuki Coupling;