(2RS,4R)-2-[3-(5-bromo-2-thienyl)-1-phenyl-1H-pyrazol-4-yl]-3-(tert-butyloxycarbonyl)oxazolidine-4-carboxylic acid

Base Information

Chemical Name:(2RS,4R)-2-[3-(5-bromo-2-thienyl)-1-phenyl-1H-pyrazol-4-yl]-3-(tert-butyloxycarbonyl)oxazolidine-4-carboxylic acid
CAS No.:612500-39-7
Molecular Formula:C₂₂H₂₂BrN₃O₅S
Molecular Weight:520.404
Hs Code.:

Synonyms:(2RS,4R)-2-[3-(5-bromo-2-thienyl)-1-phenyl-1H-pyrazol-4-yl]-3-(tert-butyloxycarbonyl)oxazolidine-4-carboxylic acid

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Chemical Property of (2RS,4R)-2-[3-(5-bromo-2-thienyl)-1-phenyl-1H-pyrazol-4-yl]-3-(tert-butyloxycarbonyl)oxazolidine-4-carboxylic acid

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Technology Process of (2RS,4R)-2-[3-(5-bromo-2-thienyl)-1-phenyl-1H-pyrazol-4-yl]-3-(tert-butyloxycarbonyl)oxazolidine-4-carboxylic acid

There total 1 articles about (2RS,4R)-2-[3-(5-bromo-2-thienyl)-1-phenyl-1H-pyrazol-4-yl]-3-(tert-butyloxycarbonyl)oxazolidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 56-45-1,83245-15-2
L-serin

: 24424-99-5
di-tert-butyl dicarbonate

: 274900-91-3
3-(5-bromo-2-thienyl)-1-phenyl-1H-pyrazole-4-carboxaldehyde

: 612500-39-7
(2RS,4R)-2-[3-(5-bromo-2-thienyl)-1-phenyl-1H-pyrazol-4-yl]-3-(tert-butyloxycarbonyl)oxazolidine-4-carboxylic acid

Guidance literature:: L-serin; 3-(5-bromo-2-thienyl)-1-phenyl-1H-pyrazole-4-carboxaldehyde; With sodium hydroxide; In ethanol; at 5 ℃; for 24h;

di-tert-butyl dicarbonate; With hydrogenchloride; In 1,4-dioxane; ethanol; at 20 ℃; for 5h; pH=9.5;
DOI:10.1002/ardp.200390007

Reference yield: 86.0%

: 612500-39-7
(2RS,4R)-2-[3-(5-bromo-2-thienyl)-1-phenyl-1H-pyrazol-4-yl]-3-(tert-butyloxycarbonyl)oxazolidine-4-carboxylic acid

: (2RS,4R)-2-[3-(5-bromo-2-thienyl)-1-phenyl-1H-pyrazol-4-yl]oxazolidine-4-carboxylic acid

Guidance literature:: With hydrogenchloride; methoxybenzene; In 1,4-dioxane; at 20 ℃; for 1h;
DOI:10.1002/ardp.200390007

Reference yield: 68.0%

: 612500-39-7
(2RS,4R)-2-[3-(5-bromo-2-thienyl)-1-phenyl-1H-pyrazol-4-yl]-3-(tert-butyloxycarbonyl)oxazolidine-4-carboxylic acid

: 612500-45-5
(2RS,4R)-2-[3-(5-bromo-2-thienyl)-1-phenyl-1H-pyrazol-4-yl]-3-(tert-butyloxycarbonyl)oxazolidine-4-carboxamide

Guidance literature:: (2RS,4R)-2-[3-(5-bromo-2-thienyl)-1-phenyl-1H-pyrazol-4-yl]-3-(tert-butyloxycarbonyl)oxazolidine-4-carboxylic acid; With N,N'-dicyclohexyl-carbodiimide hydrochloride; benzotriazol-1-ol; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

With ammonium hydroxide; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1002/ardp.200390007