Fospropofol

Base Information

Chemical Name:Fospropofol
CAS No.:258516-89-1
Molecular Formula:C13H21 O5 P
Molecular Weight:288.28
Hs Code.:
UNII:LZ257RZP7K
DSSTox Substance ID:DTXSID50870295
Wikipedia:Fospropofol
Wikidata:Q5473368
NCI Thesaurus Code:C76954
Pharos Ligand ID:RFR34A3YB8AL
Metabolomics Workbench ID:149926
ChEMBL ID:CHEMBL1201766
Mol file:258516-89-1.mol

Synonyms:Aquavan;fospropofol;fospropofol disodium;GPI 15715;GPI15715;lusedra;methanol, (2,6-bis(1-methylethyl)phenoxy)-, dihydrogen phosphate, disodium salt

Suppliers and Price of Fospropofol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
FOSPROPOFOL 95.00%
5MG
$ 502.17

Total 19 raw suppliers

Chemical Property of Fospropofol

Chemical Property:

PSA：85.80000
Density:1.205
LogP:3.37900
XLogP3:2.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:288.11266076
Heavy Atom Count:19
Complexity:296

Purity/Quality:

99% ^*data from raw suppliers

FOSPROPOFOL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)C1=C(C(=CC=C1)C(C)C)OCOP(=O)(O)O
Recent ClinicalTrials:Preventing Propofol Injection Pain: Prospective Randomized Trial Comparing Propofol Versus Fospropofol
Uses Procedural sedation.

Technology Process of Fospropofol

There total 3 articles about Fospropofol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 258516-82-4
2-(chloromethoxy)-1,3-diisopropylbenzene

: 258516-89-1
fospropofol

Guidance literature:: With phosphoric acid; triethylamine; In acetonitrile; at 60 - 65 ℃; for 6h;

Reference yield:

: 2078-54-8
2,6-diisopropylphenol

: 258516-89-1
fospropofol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / dichloromethane / 0 - 20 °C

2: phosphorus pentachloride / N,N-dimethyl-formamide / 70 °C

3: triethylamine; phosphoric acid / acetonitrile / 6 h / 60 - 65 °C

With phosphoric acid; phosphorus pentachloride; sodium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 2944-52-7
2,6-diisopropyl anisole

: 258516-89-1
fospropofol

Guidance literature:: Multi-step reaction with 2 steps

1: phosphorus pentachloride / N,N-dimethyl-formamide / 70 °C

2: triethylamine; phosphoric acid / acetonitrile / 6 h / 60 - 65 °C

With phosphoric acid; phosphorus pentachloride; triethylamine; In N,N-dimethyl-formamide; acetonitrile;