endo-2-phenyl-1,1a,2,2a-tetrahydro-7H-cyclobutindene

• Chemical Name: endo-2-phenyl-1,1a,2,2a-tetrahydro-7H-cyclobutindene
• Molecular Formula: C₁₇H₁₆
• Molecular Weight: 220.314
• Mol file: 72261-57-5.mol

Synonyms:endo-2-phenyl-1,1a,2,2a-tetrahydro-7H-cyclobutindene

Chemical Property of endo-2-phenyl-1,1a,2,2a-tetrahydro-7H-cyclobut

Chemical Property:

Purity/Quality:

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Technology Process of endo-2-phenyl-1,1a,2,2a-tetrahydro-7H-cyclobut

There total 11 articles about endo-2-phenyl-1,1a,2,2a-tetrahydro-7H-cyclobutindene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-phenyl-1a,2a-dihydro-7H-cyclobutindene (138089-68-6) → endo-2-phenyl-1,1a,2,2a-tetrahydro-7H-cyclobutindene (72261-57-5)

Guidance literature:

With hydrogen; palladium on activated charcoal;

DOI:10.1021/ja00536a025

Reference yield:

2,2-diphenyl-1,1a,2,2a-tetrahydro-7H-cyclobutinden-1-one (3582-45-4,100410-70-6) → endo-2-phenyl-1,1a,2,2a-tetrahydro-7H-cyclobutindene (72261-57-5)

Guidance literature:

Multi-step reaction with 7 steps

1: 92 percent / diethyl ether / 3 h

2: DCNB / Irradiation

3: 78 percent / benzene / 16 h / Irradiation

4: 92 percent / lithium aluminium hydride

5: sodium hydroxide

6: 44 percent / sodium hydroxide / H₂O / 200 °C

7: 80 percent / hydrogen / 5percent palladium-carbon

With sodium hydroxide; lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal; In diethyl ether; water; benzene;

DOI:10.1021/ja00536a025

Reference yield:

(Z)-nitrostyrene (15241-23-3) → endo-2-phenyl-1,1a,2,2a-tetrahydro-7H-cyclobutindene (72261-57-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 78 percent / benzene / 16 h / Irradiation

2: 92 percent / lithium aluminium hydride

3: sodium hydroxide

4: 44 percent / sodium hydroxide / H₂O / 200 °C

5: 80 percent / hydrogen / 5percent palladium-carbon

With sodium hydroxide; lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal; In water; benzene;

DOI:10.1021/ja00536a025

upstream raw materials:

2-phenyl-1a,2a-dihydro-7H-cyclobutindene

(Z)-nitrostyrene

cis,syn-cyclobutadiindene

exo-1-nitro-endo-2-phenyl-1,1a,2,2a-tetrahydro-7H-cyclobutindene

Downstream raw materials:

styrene

1-indene