(E)-tert-butyl 4-(4-(2-(2-cyclopropylvinyl)-5-oxo-5,6-dihydropyrido[3,2-d]pyridazin-4-ylamino)-3-methoxyphenyl)piperidine-1-carboxylate

Base Information

Chemical Name:(E)-tert-butyl 4-(4-(2-(2-cyclopropylvinyl)-5-oxo-5,6-dihydropyrido[3,2-d]pyridazin-4-ylamino)-3-methoxyphenyl)piperidine-1-carboxylate
CAS No.:1390658-02-2
Molecular Formula:C₂₉H₃₅N₅O₄
Molecular Weight:517.628
Hs Code.:

Synonyms:(E)-tert-butyl 4-(4-(2-(2-cyclopropylvinyl)-5-oxo-5,6-dihydropyrido[3,2-d]pyridazin-4-ylamino)-3-methoxyphenyl)piperidine-1-carboxylate

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Chemical Property of (E)-tert-butyl 4-(4-(2-(2-cyclopropylvinyl)-5-oxo-5,6-dihydropyrido[3,2-d]pyridazin-4-ylamino)-3-methoxyphenyl)piperidine-1-carboxylate

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Technology Process of (E)-tert-butyl 4-(4-(2-(2-cyclopropylvinyl)-5-oxo-5,6-dihydropyrido[3,2-d]pyridazin-4-ylamino)-3-methoxyphenyl)piperidine-1-carboxylate

There total 11 articles about (E)-tert-butyl 4-(4-(2-(2-cyclopropylvinyl)-5-oxo-5,6-dihydropyrido[3,2-d]pyridazin-4-ylamino)-3-methoxyphenyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 849061-99-0
(E)-4,4,5,5-tetramethyl-2-(cyclopropyl-1-ethenyl)-1,3,2-dioxaborolane

: 1390657-97-2
tert-butyl 4-(4-((2-chloro-5-oxo-5,6-dihydropyrido[2,3-d]pyridazin-4-yl)amino)-3-methoxyphenyl)piperidine-1-carboxylate

: 1390658-02-2
(E)-tert-butyl 4-(4-(2-(2-cyclopropylvinyl)-5-oxo-5,6-dihydropyrido[3,2-d]pyridazin-4-ylamino)-3-methoxyphenyl)piperidine-1-carboxylate

Guidance literature:: With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; at 100 ℃; for 4h; Inert atmosphere;

Reference yield:

: 375853-82-0,286961-14-6
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

: 1390658-02-2
(E)-tert-butyl 4-(4-(2-(2-cyclopropylvinyl)-5-oxo-5,6-dihydropyrido[3,2-d]pyridazin-4-ylamino)-3-methoxyphenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 15 h / 90 °C / Inert atmosphere

2: hydrogen / palladium 10% on activated carbon / methanol / 8 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 18 h / 130 °C / Sealed tube

4: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

With hydrogen; sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In 1,4-dioxane; methanol; water;

Reference yield:

: 686279-09-4
ethyl 4,6-dichloro-2-methylpyridine-3-carboxylate

: 1390658-02-2
(E)-tert-butyl 4-(4-(2-(2-cyclopropylvinyl)-5-oxo-5,6-dihydropyrido[3,2-d]pyridazin-4-ylamino)-3-methoxyphenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 24 h / 85 °C

2: N-methylpiperidine-N-oxide / acetonitrile / 1 h / 20 °C / Molecular sieve

3: 1,4-dioxane / 15 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 18 h / 130 °C / Sealed tube

6: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

With N-methylpiperidine-N-oxide; N-Bromosuccinimide; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; dibenzoyl peroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; tetrachloromethane; dichloromethane; water; acetonitrile;