(1R,2S,3S,5R,6R*)-tert-butyldimethyl<(3-((tert-butyldimethylsilyl)oxy)-2,6-dimethyl-5-hydroxy-4-oxo-1-cyclohexyl)oxy>silane

Base Information

Chemical Name:(1R*,2S*,3S*,5R*,6R*)-tert-butyldimethyl<(3-((tert-butyldimethylsilyl)oxy)-2,6-dimethyl-5-hydroxy-4-oxo-1-cyclohexyl)oxy>silane
CAS No.:103383-25-1
Molecular Formula:C₂₀H₄₂O₄Si₂
Molecular Weight:402.722
Hs Code.:

Synonyms:(1R*,2S*,3S*,5R*,6R*)-tert-butyldimethyl<(3-((tert-butyldimethylsilyl)oxy)-2,6-dimethyl-5-hydroxy-4-oxo-1-cyclohexyl)oxy>silane

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Chemical Property of (1R*,2S*,3S*,5R*,6R*)-tert-butyldimethyl<(3-((tert-butyldimethylsilyl)oxy)-2,6-dimethyl-5-hydroxy-4-oxo-1-cyclohexyl)oxy>silane

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Technology Process of (1R*,2S*,3S*,5R*,6R*)-tert-butyldimethyl<(3-((tert-butyldimethylsilyl)oxy)-2,6-dimethyl-5-hydroxy-4-oxo-1-cyclohexyl)oxy>silane

There total 11 articles about (1R*,2S*,3S*,5R*,6R*)-tert-butyldimethyl<(3-((tert-butyldimethylsilyl)oxy)-2,6-dimethyl-5-hydroxy-4-oxo-1-cyclohexyl)oxy>silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103367-78-8
(3R*,4R*,5R*,6S*)-<(3,5-dimethyl-4,6-bis((tert-butyldimethylsilyl)oxy)-1-cyclohexenyl)oxy>trimethylsilane

: 103383-25-1
(1R*,2S*,3S*,5R*,6R*)-tert-butyldimethyl<(3-((tert-butyldimethylsilyl)oxy)-2,6-dimethyl-5-hydroxy-4-oxo-1-cyclohexyl)oxy>silane

Guidance literature:: With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In tetrahydrofuran; water; for 48h; Ambient temperature;
DOI:10.1021/ja00278a031

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 103383-25-1
(1R*,2S*,3S*,5R*,6R*)-tert-butyldimethyl<(3-((tert-butyldimethylsilyl)oxy)-2,6-dimethyl-5-hydroxy-4-oxo-1-cyclohexyl)oxy>silane

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 °C

2: p-TsOH-H₂O / acetone / 48 h / Heating

3: LDA, / tetrahydrofuran / 1.) -78 deg C, 1 h; 2.) -78 deg C, 1.5 h then 1 h room temperature

4: 4.54 g / N-methylmorpholine N-oxide, OsO₄ / tetrahydrofuran; H₂O / Ambient temperature

5: 15.49 g / imidazole / dimethylformamide / Ambient temperature

6: LDA / tetrahydrofuran / 1.) -30 deg C, 1.5 h; 2.) 1 h, room temperature

7: N-methylmorpholine N-oxide, OsO₄ / tetrahydrofuran; H₂O / 48 h / Ambient temperature

With 1H-imidazole; 2,6-dimethylpyridine; osmium(VIII) oxide; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ja00278a031

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 103383-25-1
(1R*,2S*,3S*,5R*,6R*)-tert-butyldimethyl<(3-((tert-butyldimethylsilyl)oxy)-2,6-dimethyl-5-hydroxy-4-oxo-1-cyclohexyl)oxy>silane

Guidance literature:: Multi-step reaction with 3 steps

1: 15.49 g / imidazole / dimethylformamide / Ambient temperature

2: LDA / tetrahydrofuran / 1.) -30 deg C, 1.5 h; 2.) 1 h, room temperature

3: N-methylmorpholine N-oxide, OsO₄ / tetrahydrofuran; H₂O / 48 h / Ambient temperature

With 1H-imidazole; osmium(VIII) oxide; 4-methylmorpholine N-oxide; lithium diisopropyl amide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/ja00278a031