Sorafenib Impurity 6

Base Information

Chemical Name:Sorafenib Impurity 6
CAS No.:1285533-84-7
Molecular Formula:C₂₁H₁₇F₃N₄O₃
Molecular Weight:430.386
Hs Code.:
Mol file:1285533-84-7.mol

Synonyms:4-[4-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methylpyridine-2-carboxamide

Suppliers and Price of Sorafenib Impurity 6

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-Methyl-4-[4-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-2-pyridinecarboxamide
1g
$ 1390.00

Matrix Scientific
N-Methyl-4-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenoxy)picolinamide 95%
1g
$ 2550.00

Matrix Scientific
N-Methyl-4-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenoxy)picolinamide 95%
250mg
$ 765.00

Total 12 raw suppliers

Chemical Property of Sorafenib Impurity 6

Chemical Property:

Melting Point:187.6 °C
Boiling Point:498.1±45.0 °C(Predicted)
PKA:13.39±0.70(Predicted)
Density:1.399±0.06 g/cm3(Predicted)

Purity/Quality:

≥99% ^*data from raw suppliers

N-Methyl-4-[4-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-2-pyridinecarboxamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses N-Methyl-4-[4-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-2-pyridinecarboxamide is an impurity of Sorafenib (S676850); a multiple kinase inhibitor targeting both RAF and receptor tyrosine kinases that promote angiogenesis. Also antineoplastic.

Technology Process of Sorafenib Impurity 6

There total 8 articles about Sorafenib Impurity 6 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1285533-84-7
4-[4-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methylpyridine-2-carboxamide

Guidance literature:: In dichloromethane; at 0 ℃; for 17h; Inert atmosphere;

Reference yield: 84.0%

: 284462-37-9
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

: 329-01-1
1-isocyanato-3-trifluoromethyl-benzene

: 1285533-84-7
4-[4-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methylpyridine-2-carboxamide

Guidance literature:: In dichloromethane; for 24h;

Reference yield:

: 5470-22-4
4-chloropicolinic acid

: 1285533-84-7
4-[4-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methylpyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 15.5 h / 0 - 20 °C / Inert atmosphere

2.1: tetrahydrofuran / 16.42 h / 0 - 20 °C / Inert atmosphere

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 2.02 h / Inert atmosphere

3.2: 4 h / 80 °C / Inert atmosphere

4.1: dichloromethane / 24 h

With oxalyl dichloride; potassium tert-butylate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;