C₆₀H₆₇Cl₂NO₁₅Si

Base Information

• Chemical Name: C₆₀H₆₇Cl₂NO₁₅Si
• CAS No.: 220178-06-3
• Molecular Formula: C₆₀H₆₇Cl₂NO₁₅Si
• Molecular Weight: 1141.18
• Mol file: 220178-06-3.mol

Synonyms:C₆₀H₆₇Cl₂NO₁₅Si

Chemical Property of C₆₀H₆₇Cl₂NO₁₅Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of C₆₀H₆₇Cl₂NO₁₅Si

There total 3 articles about C₆₀H₆₇Cl₂NO₁₅Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

taxol (33069-62-4) → C60H67Cl2NO15Si (220178-06-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / DMAP / dimethylformamide / 24 h / Ambient temperature

2: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, DMAP / CH₂Cl₂ / 1.67 h / Ambient temperature

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(98)00551-4

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → C60H67Cl2NO15Si (220178-06-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / DMAP / dimethylformamide / 24 h / Ambient temperature

2: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, DMAP / CH₂Cl₂ / 1.67 h / Ambient temperature

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(98)00551-4

Reference yield:

3,4-dichlorbenzoic acid (51-44-5) + 2'-O-(tert-butyldimethylsilyl)paclitaxel (114655-02-6) → C60H67Cl2NO15Si (220178-06-3)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 1.66667h; Yield given; Ambient temperature;

DOI:10.1016/S0960-894X(98)00551-4

upstream raw materials:

3,4-dichlorbenzoic acid

2'-O-(tert-butyldimethylsilyl)paclitaxel

taxol

tert-butyldimethylsilyl chloride