[3-tert-butyl-5-[(4,5-dibutylimidazolyl)methyl]phenyl]acetonitrile

Base Information

• Chemical Name: [3-tert-butyl-5-[(4,5-dibutylimidazolyl)methyl]phenyl]acetonitrile
• CAS No.: 339064-27-6
• Molecular Formula: C₂₄H₃₅N₃
• Molecular Weight: 365.562
• Mol file: 339064-27-6.mol

Synonyms:[3-tert-butyl-5-[(4,5-dibutylimidazolyl)methyl]phenyl]acetonitrile

Chemical Property of [3-tert-butyl-5-[(4,5-dibutylimidazolyl)methyl]phenyl]acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [3-tert-butyl-5-[(4,5-dibutylimidazolyl)methyl]phenyl]acetonitrile

There total 6 articles about [3-tert-butyl-5-[(4,5-dibutylimidazolyl)methyl]phenyl]acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

sodium cyanide (143-33-9,25596-52-5) + 4,5-dibutyl-1-[[3-tert-butyl-5-(chloromethyl)phenyl]methyl]imidazolium chloride → [3-tert-butyl-5-[(4,5-dibutylimidazolyl)methyl]phenyl]acetonitrile (339064-27-6)

Guidance literature:

In N,N-dimethyl-formamide; at 80 ℃; for 24h;

DOI:10.1021/jo0056794

Reference yield:

4,5-dibutyl-1H-imidazole (79073-01-1) → [3-tert-butyl-5-[(4,5-dibutylimidazolyl)methyl]phenyl]acetonitrile (339064-27-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / KOH / acetonitrile; dioxane / 17 h / Heating

2: 96 percent / SOCl₂ / CH₂Cl₂ / 5 h / 20 °C

3: 88 percent / dimethylformamide / 24 h / 80 °C

With potassium hydroxide; thionyl chloride; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jo0056794

Reference yield:

1,3-bis(hydroxymethyl)-5-tert-butylbenzene (22157-91-1) → [3-tert-butyl-5-[(4,5-dibutylimidazolyl)methyl]phenyl]acetonitrile (339064-27-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 81 percent / HBr conc. / 5 h / 20 °C

2: 84 percent / KOH / acetonitrile; dioxane / 17 h / Heating

3: 96 percent / SOCl₂ / CH₂Cl₂ / 5 h / 20 °C

4: 88 percent / dimethylformamide / 24 h / 80 °C

With potassium hydroxide; thionyl chloride; hydrogen bromide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jo0056794

upstream raw materials:

sodium cyanide

4,5-dibutyl-1H-imidazole

1,3-bis(hydroxymethyl)-5-tert-butylbenzene

[3-(bromomethyl)-5-tert-butylphenyl]methanol

Downstream raw materials:

3,5-bis[[[3-tert-butyl-5-(4,5-dibutylimidazolyl)methyl]phenyl]methyl]-1,2,4-triazole

4-amino-3,5-bis[[[3-tert-butyl-5-(4,5-dibutylimidazolyl)methyl]phenyl]methyl]-1,2,4-triazole