hexyl (4R)-2-[1-(4-isobutylphenyl)-ethyl]-thiazolidine-4-carboxylate hydrochloride

Base Information

• Chemical Name: hexyl (4R)-2-[1-(4-isobutylphenyl)-ethyl]-thiazolidine-4-carboxylate hydrochloride
• CAS No.: 114937-06-3
• Molecular Formula: C₂₂H₃₅NO₂S*ClH
• Molecular Weight: 414.052
• Mol file: 114937-06-3.mol

Synonyms:hexyl (4R)-2-[1-(4-isobutylphenyl)-ethyl]-thiazolidine-4-carboxylate hydrochloride

Chemical Property of hexyl (4R)-2-[1-(4-isobutylphenyl)-ethyl]-thiazolidine-4-carboxylate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of hexyl (4R)-2-[1-(4-isobutylphenyl)-ethyl]-thiazolidine-4-carboxylate hydrochloride

There total 4 articles about hexyl (4R)-2-[1-(4-isobutylphenyl)-ethyl]-thiazolidine-4-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.76%

2-(4-isobutylphenyl)propionaldehyde (51407-46-6) + (R)-cysteine hexyl ester → hexyl (4R)-2-[1-(4-isobutylphenyl)-ethyl]-thiazolidine-4-carboxylate hydrochloride (114937-06-3)

Guidance literature:

With hydrogenchloride; potassium acetate; In diethyl ether; ethanol; water;

Reference yield:

2-(4-isobutylphenyl)propan-1-ol (36039-36-8) → hexyl (4R)-2-[1-(4-isobutylphenyl)-ethyl]-thiazolidine-4-carboxylate hydrochloride (114937-06-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) oxalyl chloride, DMSO, 2) Et₃N / 1) -65 deg C, CH₂Cl₂, 5 min

2: 20 percent / potassium acetate / aq. ethanol

With oxalyl dichloride; potassium acetate; dimethyl sulfoxide; triethylamine; In ethanol;

DOI:10.1002/jhet.5570260313

Reference yield:

(+/-)-ibuprofen methyl ester (61566-34-5) → hexyl (4R)-2-[1-(4-isobutylphenyl)-ethyl]-thiazolidine-4-carboxylate hydrochloride (114937-06-3)

Guidance literature:

Multi-step reaction with 3 steps

1: NaBH₄, CaCl₂ / ethanol / -20 °C

2: 1) oxalyl chloride, DMSO, 2) Et₃N / 1) -65 deg C, CH₂Cl₂, 5 min

3: 20 percent / potassium acetate / aq. ethanol

With sodium tetrahydroborate; oxalyl dichloride; potassium acetate; dimethyl sulfoxide; triethylamine; calcium chloride; In ethanol;

DOI:10.1002/jhet.5570260313

upstream raw materials:

2-(4-isobutylphenyl)propan-1-ol

ibuprofen

(+/-)-ibuprofen methyl ester

2-(4-isobutylphenyl)propionaldehyde

Refernces

• 1、 -. "Pharmaceutically useful derivatives of thiazolidine-4-carboxylic acid". . . Retrieved 2008/06/13.