(S)-2-{[(S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-4-methyl-pentanoyl]-methyl-amino}-4-methyl-pentanoic acid benzyl ester

Base Information

Chemical Name:(S)-2-{[(S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-4-methyl-pentanoyl]-methyl-amino}-4-methyl-pentanoic acid benzyl ester
CAS No.:179669-50-2
Molecular Formula:C₂₈H₄₅N₃O₆
Molecular Weight:519.682
Hs Code.:

Synonyms:(S)-2-{[(S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-4-methyl-pentanoyl]-methyl-amino}-4-methyl-pentanoic acid benzyl ester

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Chemical Property of (S)-2-{[(S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-4-methyl-pentanoyl]-methyl-amino}-4-methyl-pentanoic acid benzyl ester

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Technology Process of (S)-2-{[(S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-4-methyl-pentanoyl]-methyl-amino}-4-methyl-pentanoic acid benzyl ester

There total 1 articles about (S)-2-{[(S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-4-methyl-pentanoyl]-methyl-amino}-4-methyl-pentanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 15761-38-3
L-N-Boc-Ala

: 179669-84-2
(S)-2-[((S)-2-Amino-4-methyl-pentanoyl)-methyl-amino]-4-methyl-pentanoic acid benzyl ester

: 179669-50-2
(S)-2-{[(S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-4-methyl-pentanoyl]-methyl-amino}-4-methyl-pentanoic acid benzyl ester

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 3h;

Reference yield:

: 179669-50-2
(S)-2-{[(S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-4-methyl-pentanoyl]-methyl-amino}-4-methyl-pentanoic acid benzyl ester

: 179669-62-6
2,2-Dimethyl-propionic acid 3-((3S,6S,9S,12S,15S)-15-benzyloxycarbonylamino-6,9-diisobutyl-7,12-dimethyl-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentaaza-cyclononadec-3-ylmethyl)-1H-indol-5-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / H₂ / Pd/C / methanol / 3 h / Ambient temperature

2: 86 percent / DPPA / dimethylformamide / 48 h / -20 °C

3: 97 percent / Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

4: 97 percent / aq. NaOH / dioxane / Ambient temperature

5: EDC / CH₂Cl₂ / 16 h

6: HCl / dioxane / 2 h / Ambient temperature

7: NaHCO₃ / CHCl₃ / 5 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; diphenyl-phosphinic acid; hydrogen; sodium hydrogencarbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 179669-50-2
(S)-2-{[(S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-4-methyl-pentanoyl]-methyl-amino}-4-methyl-pentanoic acid benzyl ester

: 179669-53-5
(S)-2-Benzyloxycarbonylamino-6-[(S)-2-((S)-2-{[(S)-2-((S)-2-tert-butoxycarbonylamino-propionylamino)-4-methyl-pentanoyl]-methyl-amino}-4-methyl-pentanoylamino)-3-(5-hydroxy-1H-indol-3-yl)-propionylamino]-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / H₂ / Pd/C / methanol / 3 h / Ambient temperature

2: 86 percent / DPPA / dimethylformamide / 48 h / -20 °C

With diphenyl-phosphinic acid; hydrogen; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;