4-nitrophenyl piperazinyl N-[1-oxyl-(4'-O-demethyl-4β-[(4-hydroxymethyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllic)]-L-methine amide

Base Information

Chemical Name:4-nitrophenyl piperazinyl N-[1-oxyl-(4'-O-demethyl-4β-[(4-hydroxymethyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllic)]-L-methine amide
CAS No.:1443920-21-5
Molecular Formula:C₄₀H₄₃N₇O₁₂S
Molecular Weight:845.887
Hs Code.:

Synonyms:4-nitrophenyl piperazinyl N-[1-oxyl-(4'-O-demethyl-4β-[(4-hydroxymethyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllic)]-L-methine amide

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Chemical Property of 4-nitrophenyl piperazinyl N-[1-oxyl-(4'-O-demethyl-4β-[(4-hydroxymethyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllic)]-L-methine amide

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Technology Process of 4-nitrophenyl piperazinyl N-[1-oxyl-(4'-O-demethyl-4β-[(4-hydroxymethyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllic)]-L-methine amide

There total 4 articles about 4-nitrophenyl piperazinyl N-[1-oxyl-(4'-O-demethyl-4β-[(4-hydroxymethyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllic)]-L-methine amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1308814-04-1
C₁₅H₂₂N₄O₃S

: 1443920-10-2
4'-demethyl-4'-benzyloxycarbonyl-4β-[(4-hydroxy methyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin p-nitrophenyl carbonate

: 1443920-21-5
4-nitrophenyl piperazinyl N-[1-oxyl-(4'-O-demethyl-4β-[(4-hydroxymethyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllic)]-L-methine amide

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.ejmech.2013.03.068

Reference yield:

: 6559-91-7
4'-demethylepipodophyllotoxin

: 1443920-21-5
4-nitrophenyl piperazinyl N-[1-oxyl-(4'-O-demethyl-4β-[(4-hydroxymethyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllic)]-L-methine amide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane

2: boron trifluoride diethyl etherate; ammonia

3: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 10 h / 20 °C

4: pyridine / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

5: triethylamine; dmap / dichloromethane / 20 °C

With pyridine; dmap; copper(ll) sulfate pentahydrate; boron trifluoride diethyl etherate; ammonia; sodium L-ascorbate; triethylamine; In dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/j.ejmech.2013.03.068

Reference yield:

: 23363-33-9
4'-demethyl-4'-O-(benzoyloxycarbonyl)epipodophyllotoxin

: 1443920-21-5
4-nitrophenyl piperazinyl N-[1-oxyl-(4'-O-demethyl-4β-[(4-hydroxymethyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllic)]-L-methine amide

Guidance literature:: Multi-step reaction with 4 steps

1: boron trifluoride diethyl etherate; ammonia

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 10 h / 20 °C

3: pyridine / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

4: triethylamine; dmap / dichloromethane / 20 °C

With pyridine; dmap; copper(ll) sulfate pentahydrate; boron trifluoride diethyl etherate; ammonia; sodium L-ascorbate; triethylamine; In dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/j.ejmech.2013.03.068