4'-demethyl-4'-benzyloxycarbonyl-4β-[(4-hydroxy methyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin p-nitrophenyl carbonate

Base Information

Chemical Name:4'-demethyl-4'-benzyloxycarbonyl-4β-[(4-hydroxy methyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin p-nitrophenyl carbonate
CAS No.:1443920-10-2
Molecular Formula:C₃₉H₃₂N₄O₁₄
Molecular Weight:780.701
Hs Code.:

Synonyms:4'-demethyl-4'-benzyloxycarbonyl-4β-[(4-hydroxy methyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin p-nitrophenyl carbonate

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Chemical Property of 4'-demethyl-4'-benzyloxycarbonyl-4β-[(4-hydroxy methyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin p-nitrophenyl carbonate

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Technology Process of 4'-demethyl-4'-benzyloxycarbonyl-4β-[(4-hydroxy methyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin p-nitrophenyl carbonate

There total 4 articles about 4'-demethyl-4'-benzyloxycarbonyl-4β-[(4-hydroxy methyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin p-nitrophenyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1443920-08-8
4'-O-demethyl-4'-benzyloxycarbonyl-4β-[(4-hydroxy methyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin

: 7693-46-1
4-Nitrophenyl chloroformate

: 1443920-10-2
4'-demethyl-4'-benzyloxycarbonyl-4β-[(4-hydroxy methyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin p-nitrophenyl carbonate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 0.75h; Inert atmosphere;
DOI:10.1016/j.ejmech.2013.03.068

Reference yield:

: 6559-91-7
4'-demethylepipodophyllotoxin

: 1443920-10-2
4'-demethyl-4'-benzyloxycarbonyl-4β-[(4-hydroxy methyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin p-nitrophenyl carbonate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane

2: boron trifluoride diethyl etherate; ammonia

3: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 10 h / 20 °C

4: pyridine / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

With pyridine; copper(ll) sulfate pentahydrate; boron trifluoride diethyl etherate; ammonia; sodium L-ascorbate; triethylamine; In dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/j.ejmech.2013.03.068

Reference yield:

: 23363-33-9
4'-demethyl-4'-O-(benzoyloxycarbonyl)epipodophyllotoxin

: 1443920-10-2
4'-demethyl-4'-benzyloxycarbonyl-4β-[(4-hydroxy methyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin p-nitrophenyl carbonate

Guidance literature:: Multi-step reaction with 3 steps

1: boron trifluoride diethyl etherate; ammonia

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 10 h / 20 °C

3: pyridine / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

With pyridine; copper(ll) sulfate pentahydrate; boron trifluoride diethyl etherate; ammonia; sodium L-ascorbate; In dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/j.ejmech.2013.03.068