methyl 1-<(2'-cyanobiphenyl-4-yl)methyl>-2-<(methylthio)ethyl>-1H-benzimidazole-7-carboxylate

Base Information

Chemical Name:methyl 1-<(2'-cyanobiphenyl-4-yl)methyl>-2-<(methylthio)ethyl>-1H-benzimidazole-7-carboxylate
CAS No.:150058-15-4
Molecular Formula:C₂₆H₂₃N₃O₂S
Molecular Weight:441.554
Hs Code.:

Synonyms:methyl 1-<(2'-cyanobiphenyl-4-yl)methyl>-2-<(methylthio)ethyl>-1H-benzimidazole-7-carboxylate

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Chemical Property of methyl 1-<(2'-cyanobiphenyl-4-yl)methyl>-2-<(methylthio)ethyl>-1H-benzimidazole-7-carboxylate

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Technology Process of methyl 1-<(2'-cyanobiphenyl-4-yl)methyl>-2-<(methylthio)ethyl>-1H-benzimidazole-7-carboxylate

There total 9 articles about methyl 1-<(2'-cyanobiphenyl-4-yl)methyl>-2-<(methylthio)ethyl>-1H-benzimidazole-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 136304-79-5
methyl 2-(2-chloroethyl)-1-[(2'-cyanobiphenyl-4-yl)methyl]benzimidazole-7-carboxylate

: 5188-07-8
sodium thiomethoxide

: 150058-15-4
methyl 1-<(2'-cyanobiphenyl-4-yl)methyl>-2-<(methylthio)ethyl>-1H-benzimidazole-7-carboxylate

Guidance literature:: In water; acetonitrile; at 60 ℃; for 2h;
DOI:10.1021/jm00067a016

Reference yield:

: 21606-04-2
methyl 2-carboxy-3-nitrobenzoate

: 150058-15-4
methyl 1-<(2'-cyanobiphenyl-4-yl)methyl>-2-<(methylthio)ethyl>-1H-benzimidazole-7-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: SOCl₂, DMF / toluene / 0.5 h / Heating

2: NaN₃ / acetone; H₂O / 1 h

3: 1.5 h / Heating

4: 85 percent / K₂CO₃ / acetonitrile / 4 h / Heating

5: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature

6: 1.) FeCl₃*6H₂O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h

7: 100 percent / CH₂Cl₂ / 2 h / Ambient temperature

8: 93 percent / acetonitrile; H₂O / 2 h / 60 °C

With hydrogenchloride; thionyl chloride; sodium azide; potassium carbonate; pyrographite; hydrazine hydrate; N,N-dimethyl-formamide; In dichloromethane; water; ethyl acetate; acetone; toluene; acetonitrile;
DOI:10.1021/jm00067a016

Reference yield:

: 73833-13-3
acid chloride of 1-methylhydrogen-3-nitrophthalate

: 150058-15-4
methyl 1-<(2'-cyanobiphenyl-4-yl)methyl>-2-<(methylthio)ethyl>-1H-benzimidazole-7-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: NaN₃ / acetone; H₂O / 1 h

2: 1.5 h / Heating

3: 85 percent / K₂CO₃ / acetonitrile / 4 h / Heating

4: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature

5: 1.) FeCl₃*6H₂O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h

6: 100 percent / CH₂Cl₂ / 2 h / Ambient temperature

7: 93 percent / acetonitrile; H₂O / 2 h / 60 °C

With hydrogenchloride; sodium azide; potassium carbonate; pyrographite; hydrazine hydrate; In dichloromethane; water; ethyl acetate; acetone; acetonitrile;
DOI:10.1021/jm00067a016