5-Hydroxy-2-methylpyrimidine

Base Information

• Chemical Name: 5-Hydroxy-2-methylpyrimidine
• CAS No.: 35231-56-2
• Molecular Formula: C5H6N2O
• Molecular Weight: 110.115
• Hs Code.: 2933599090
• Mol file: 35231-56-2.mol

Synonyms:2-Methyl-5-hydroxypyrimidine;2-Methyl-5-pyrimidinol;

Chemical Property of 5-Hydroxy-2-methylpyrimidine

Chemical Property:

• Vapor Pressure: 0.148mmHg at 25°C
• Melting Point: 175-179 °C
• Refractive Index: 1.556
• Boiling Point: 208.453 °C at 760 mmHg
• PKA: 6.92±0.23(Predicted)
• Flash Point: 79.87 °C
• PSA: 46.01000
• Density: 1.216 g/cm³
• LogP: 0.49060
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Methyl-5-pyrimidinol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Pyrimidinyl derivative as insecticide intermediate.

Technology Process of 5-Hydroxy-2-methylpyrimidine

There total 2 articles about 5-Hydroxy-2-methylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ 5-hydroxy-2-methylpyrimidine (35231-56-2)

Guidance literature:

Reference yield: 40.0%

5-bromo-2-methylpyrimidine (7752-78-5) → 5-hydroxy-2-methylpyrimidine (35231-56-2)

Guidance literature:

With sodium methylate; In methanol; at 180 ℃; for 7h;

DOI:10.1007/BF00479612

Reference yield: 98.0%

ethyl 1-(4-fluorophenyl)-6-(hydroxymethyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate + 5-hydroxy-2-methylpyrimidine (35231-56-2) → ethyl 1-(4-fluorophenyl)-6-(((2-methylpyrimidin-5-yl)oxy)methyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate

Guidance literature:

With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; for 16h;

DOI:10.1021/acs.jmedchem.5b01371

upstream raw materials:

5-bromo-2-methylpyrimidine

Downstream raw materials:

C₃₃H₃₉FN₈O₆

Refernces

• 1、 -. "HYDANTOIN DERIVATIVES USED AS MMP INHIBITORS". Page/Page column 34. . Retrieved 2008/12/06.