(S)-2-[(E)-(S)-2-Methoxymethyl-pyrrolidin-1-ylimino]-1-methyl-cyclohexanecarbonitrile

Base Information

Chemical Name:(S)-2-[(E)-(S)-2-Methoxymethyl-pyrrolidin-1-ylimino]-1-methyl-cyclohexanecarbonitrile
CAS No.:152297-24-0
Molecular Formula:C₁₄H₂₃N₃O
Molecular Weight:249.356
Hs Code.:

Synonyms:(S)-2-[(E)-(S)-2-Methoxymethyl-pyrrolidin-1-ylimino]-1-methyl-cyclohexanecarbonitrile

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Chemical Property of (S)-2-[(E)-(S)-2-Methoxymethyl-pyrrolidin-1-ylimino]-1-methyl-cyclohexanecarbonitrile

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Technology Process of (S)-2-[(E)-(S)-2-Methoxymethyl-pyrrolidin-1-ylimino]-1-methyl-cyclohexanecarbonitrile

There total 3 articles about (S)-2-[(E)-(S)-2-Methoxymethyl-pyrrolidin-1-ylimino]-1-methyl-cyclohexanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59983-39-0,187035-29-6
(S)-1-amino-2-(methoxymethyl)pyrrolidine

: 152297-24-0
(S)-2-[(E)-(S)-2-Methoxymethyl-pyrrolidin-1-ylimino]-1-methyl-cyclohexanecarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / p-TsOH / cyclohexane / 12 h / Heating

2: 1) LDA / 1) Et₂O, -78 deg C to r.t., overnight, 2) -110 deg C to r.t.

With toluene-4-sulfonic acid; lithium diisopropyl amide; In cyclohexane;
DOI:10.1055/s-1993-25929

Reference yield:

: 4513-77-3
2-cyanocyclohexanone

: 152297-24-0
(S)-2-[(E)-(S)-2-Methoxymethyl-pyrrolidin-1-ylimino]-1-methyl-cyclohexanecarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / p-TsOH / cyclohexane / 12 h / Heating

2: 1) LDA / 1) Et₂O, -78 deg C to r.t., overnight, 2) -110 deg C to r.t.

With toluene-4-sulfonic acid; lithium diisopropyl amide; In cyclohexane;
DOI:10.1055/s-1993-25929

Reference yield:

: (2S)-1-<(2R/S)-2-cyanocyclohexylideneamino>-2-methoxymethylpyrrolidine

: 74-88-4
methyl iodide

: (R)-2-[(E)-(S)-2-Methoxymethyl-pyrrolidin-1-ylimino]-1-methyl-cyclohexanecarbonitrile

: 152297-24-0
(S)-2-[(E)-(S)-2-Methoxymethyl-pyrrolidin-1-ylimino]-1-methyl-cyclohexanecarbonitrile

Guidance literature:: With lithium diisopropyl amide; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1) Et₂O, -78 deg C to r.t., overnight, 2) -110 deg C to r.t.;
DOI:10.1055/s-1993-25929