4-[4-chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]-morpholine

Base Information

• Chemical Name: 4-[4-chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]-morpholine
• CAS No.: 1007205-47-1
• Molecular Formula: C₁₇H₁₉Cl₂N₃O₂
• Molecular Weight: 368.263

Synonyms:4-[4-chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]-morpholine

Chemical Property of 4-[4-chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]-morpholine

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Technology Process of 4-[4-chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]-morpholine

There total 3 articles about 4-[4-chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]-morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-(2-hydroxyethyl)-6-(3-methoxyphenyl)-2-morpholin-4-yl-pyrimidin-4-ol (1007205-45-9) → 4-[4-chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]-morpholine (1007205-47-1)

Guidance literature:

With trichlorophosphate; at 110 ℃; for 24h; Product distribution / selectivity;

Reference yield: 91.0%

4-(3-methoxyphenyl)-2-(morpholin-4-yl)-5,6-dihydro-furo[2,3-d]pyrimidine → 4-[4-chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]-morpholine (1007205-47-1)

Guidance literature:

With trichlorophosphate; at 110 ℃; for 96h; Product distribution / selectivity;

Reference yield:

m-anisoyl chloride (1711-05-3) → 4-[4-chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]-morpholine (1007205-47-1)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C

2: sodium t-butanolate / tert-butyl alcohol / 120 °C

3: trichlorophosphate / 110 °C

With lithium hexamethyldisilazane; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; tert-butyl alcohol;

DOI:10.1016/j.bmcl.2011.01.065

upstream raw materials:

5-(2-hydroxyethyl)-6-(3-methoxyphenyl)-2-morpholin-4-yl-pyrimidin-4-ol

m-anisoyl chloride

Downstream raw materials:

7-(2-chloro-pyridin-4-yl)-4-(3-methoxy-phenyl)-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

4-(3-methoxy-phenyl)-2-morpholin-4-yl-7-pyridin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

4-(3-Methoxy-phenyl)-7-[2-(4-methyl-piperazin-1-yl)-pyridin-4-yl]-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

(2-{4-[4-(3-Methoxy-phenyl)-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl]-pyridin-2-yloxy}-ethyl)-dimethyl-amine

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