7-(2-chloro-pyridin-4-yl)-4-(3-methoxy-phenyl)-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

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Chemical Name:7-(2-chloro-pyridin-4-yl)-4-(3-methoxy-phenyl)-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine
CAS No.:1007214-80-3
Molecular Formula:C₂₂H₂₂ClN₅O₂
Molecular Weight:423.902
Hs Code.:

Synonyms:7-(2-chloro-pyridin-4-yl)-4-(3-methoxy-phenyl)-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

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Chemical Property of 7-(2-chloro-pyridin-4-yl)-4-(3-methoxy-phenyl)-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

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Technology Process of 7-(2-chloro-pyridin-4-yl)-4-(3-methoxy-phenyl)-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

There total 1 articles about 7-(2-chloro-pyridin-4-yl)-4-(3-methoxy-phenyl)-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 14432-12-3
4-Amino-2-chloropyridine

: 1007205-47-1
4-[4-chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]-morpholine

: 1007214-80-3
7-(2-chloro-pyridin-4-yl)-4-(3-methoxy-phenyl)-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: 4-Amino-2-chloropyridine; With sodium hydride; In tetrahydrofuran; for 1.5h; Heating / reflux;

4-[4-chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]-morpholine; In tetrahydrofuran; for 1.5h; Heating / reflux;

Reference yield: 33.0%

: 625-43-4
2-methylpropyl(methyl)amine

: 1007214-80-3
7-(2-chloro-pyridin-4-yl)-4-(3-methoxy-phenyl)-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

: 1007214-84-7
3-{7-[2-(isobutyl-methyl-amino)-pyridin-4-yl]-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}-phenol

Guidance literature:: 2-methylpropyl(methyl)amine; 7-(2-chloro-pyridin-4-yl)-4-(3-methoxy-phenyl)-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine; 1-(n-butyl)-3-methylimidazolium triflate; In butan-1-ol; at 210 ℃; for 3h; under 14480.5 Torr; Microwave irradiation;

With sodium thioethylate; In N,N-dimethyl-formamide; at 150 ℃; for 0.75h;

Reference yield: 10.0%

: 1007214-80-3
7-(2-chloro-pyridin-4-yl)-4-(3-methoxy-phenyl)-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

: 156-87-6
propan-1-ol-3-amine

: 76-05-1
trifluoroacetic acid

: 1007214-82-5
3-{7-[2-(3-hydroxy-propylamino)-pyridin-4-yl]-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}-phenol trifluoroacetate

Guidance literature:: 7-(2-chloro-pyridin-4-yl)-4-(3-methoxy-phenyl)-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine; propan-1-ol-3-amine; at 180 ℃; for 16h;

With sodium thioethylate; In N,N-dimethyl-formamide; at 150 ℃; for 0.75h;

trifluoroacetic acid;