Technology Process of 5-fluoro-2-((trimethylsilyl)ethynyl)pyridin-3-amine
There total 1 articles about 5-fluoro-2-((trimethylsilyl)ethynyl)pyridin-3-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine;
at 0 - 20 ℃;
for 4h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 20 °C / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 20 °C
2.2: 0 - 20 °C
With
sodium hydride;
In
tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 20 °C / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 20 °C
2.2: 0 - 20 °C
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C
4.1: N,N-Dimethylcarbamoyl chloride / 1,2-dichloro-ethane / 80 °C / Inert atmosphere
5.1: tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
5.2: Inert atmosphere
6.1: hydroxylamine hydrochloride; sodium acetate / ethanol / 1 h / 60 °C
With
hydroxylamine hydrochloride; sodium acetate; sodium hydride; 3-chloro-benzenecarboperoxoic acid; N,N-Dimethylcarbamoyl chloride;
In
tetrahydrofuran; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; mineral oil;
