5-[[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-[2-(2,3,4,5,6,7-hexahydro-1H-3-benzazonino)carbonyl]]-6-[[(1-adamantanemethyl)amino]carbonyl]benzimidasole

Base Information

Chemical Name:5-[[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-[2-(2,3,4,5,6,7-hexahydro-1H-3-benzazonino)carbonyl]]-6-[[(1-adamantanemethyl)amino]carbonyl]benzimidasole
CAS No.:192134-00-2
Molecular Formula:C₅₅H₅₅N₅O₇
Molecular Weight:898.071
Hs Code.:

5-[[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-[2-(2,3,4,5,6,7-hexahydro-1H-3-benzazonino)carbonyl]]-6-[[(1-adamantanemethyl)amino]carbonyl]benzimidasole

Synonyms:5-[[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-[2-(2,3,4,5,6,7-hexahydro-1H-3-benzazonino)carbonyl]]-6-[[(1-adamantanemethyl)amino]carbonyl]benzimidasole

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Chemical Property of 5-[[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-[2-(2,3,4,5,6,7-hexahydro-1H-3-benzazonino)carbonyl]]-6-[[(1-adamantanemethyl)amino]carbonyl]benzimidasole

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Technology Process of 5-[[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-[2-(2,3,4,5,6,7-hexahydro-1H-3-benzazonino)carbonyl]]-6-[[(1-adamantanemethyl)amino]carbonyl]benzimidasole

There total 6 articles about 5-[[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-[2-(2,3,4,5,6,7-hexahydro-1H-3-benzazonino)carbonyl]]-6-[[(1-adamantanemethyl)amino]carbonyl]benzimidasole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17768-41-1
adamantylmethylamine

: 192133-96-3
5-{[3-(6-Carboxy-3H-benzoimidazole-5-carbonyl)-2,3,4,5,6,7-hexahydro-1H-benzo[d]azonine-2-carbonyl]-amino}-isophthalic acid dibenzyl ester

: 192134-00-2
5-[[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-[2-(2,3,4,5,6,7-hexahydro-1H-3-benzazonino)carbonyl]]-6-[[(1-adamantanemethyl)amino]carbonyl]benzimidasole

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In dichloromethane;
DOI:10.1016/S0960-894X(97)00211-4

Reference yield:

: 167993-16-0
benzimidazole-5,6-dicarboxylic acid anhydride

: 192134-00-2
5-[[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-[2-(2,3,4,5,6,7-hexahydro-1H-3-benzazonino)carbonyl]]-6-[[(1-adamantanemethyl)amino]carbonyl]benzimidasole

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / 3 h / Heating

2: 96 mg / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole; DMAP / dimethylformamide / 17 h / 20 °C

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0223-5234(02)01351-X

Reference yield:

: 2,3,4,5,6,7-Hexahydro-1H-benzo[d]azonine-2-carboxylic acid; hydrochloride

: 192134-00-2
5-[[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-[2-(2,3,4,5,6,7-hexahydro-1H-3-benzazonino)carbonyl]]-6-[[(1-adamantanemethyl)amino]carbonyl]benzimidasole

Guidance literature:: Multi-step reaction with 5 steps

1: 76 percent / Et₃N / H₂O; dioxane / 48 h / 20 °C

2: diisopropylethylamine; bromotris(pyrrolidine)phosphonium hexafluorophosphate; DMAP / CH₂Cl₂ / 19 h / 20 °C

3: 187 mg / trifluoroacetic acid / 1 h / 20 °C

4: acetonitrile / 3 h / Heating

5: 96 mg / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole; DMAP / dimethylformamide / 17 h / 20 °C

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0223-5234(02)01351-X