N-(4-chlorobenzyl)-2-(4-fluorophenyl)-4-vinyl-2,5-dihydrofuran-3-carboxamide

Base Information

Chemical Name:N-(4-chlorobenzyl)-2-(4-fluorophenyl)-4-vinyl-2,5-dihydrofuran-3-carboxamide
CAS No.:1358031-61-4
Molecular Formula:C₂₀H₁₇ClFNO₂
Molecular Weight:357.812
Hs Code.:

Synonyms:N-(4-chlorobenzyl)-2-(4-fluorophenyl)-4-vinyl-2,5-dihydrofuran-3-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-chlorobenzyl)-2-(4-fluorophenyl)-4-vinyl-2,5-dihydrofuran-3-carboxamide

Chemical Property:

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Technology Process of N-(4-chlorobenzyl)-2-(4-fluorophenyl)-4-vinyl-2,5-dihydrofuran-3-carboxamide

There total 4 articles about N-(4-chlorobenzyl)-2-(4-fluorophenyl)-4-vinyl-2,5-dihydrofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-(4-fluorophenyl)-4-vinyl-2,5-dihydrofuran-3-carboxylic acid chloride

: 104-86-9
4-chlorobenzylamine

: 1358031-61-4
N-(4-chlorobenzyl)-2-(4-fluorophenyl)-4-vinyl-2,5-dihydrofuran-3-carboxamide

Guidance literature:: In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.ejmech.2011.11.036

Reference yield:

: 1309359-51-0
2-(4-fluorophenyl)-4-vinyl-2,5-dihydrofuran-3-carboxylic acid

: 1358031-61-4
N-(4-chlorobenzyl)-2-(4-fluorophenyl)-4-vinyl-2,5-dihydrofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 4 h / Reflux

2: tetrahydrofuran / 20 °C

With thionyl chloride; In tetrahydrofuran;
DOI:10.1016/j.ejmech.2011.11.036

Reference yield:

: 790-53-4
diethyl 2-(4-fluorobenzylidene)malonate

: 1358031-61-4
N-(4-chlorobenzyl)-2-(4-fluorophenyl)-4-vinyl-2,5-dihydrofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 20 °C / Inert atmosphere

1.2: 15 h / 40 °C / Inert atmosphere

1.3: 20 - 40 °C / Inert atmosphere

2.1: thionyl chloride / 4 h / Reflux

3.1: tetrahydrofuran / 20 °C

With thionyl chloride; sodium hydride; In tetrahydrofuran; mineral oil;
DOI:10.1016/j.ejmech.2011.11.036