6-benzyloxy-7-methoxy-2-methyl-N-(2-(thiophen-2-yl)ethyl)quinoline-3-carboxamide

Base Information

Chemical Name:6-benzyloxy-7-methoxy-2-methyl-N-(2-(thiophen-2-yl)ethyl)quinoline-3-carboxamide
CAS No.:1426814-47-2
Molecular Formula:C₂₅H₂₄N₂O₃S
Molecular Weight:432.543
Hs Code.:

Synonyms:6-benzyloxy-7-methoxy-2-methyl-N-(2-(thiophen-2-yl)ethyl)quinoline-3-carboxamide

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Chemical Property of 6-benzyloxy-7-methoxy-2-methyl-N-(2-(thiophen-2-yl)ethyl)quinoline-3-carboxamide

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Technology Process of 6-benzyloxy-7-methoxy-2-methyl-N-(2-(thiophen-2-yl)ethyl)quinoline-3-carboxamide

There total 6 articles about 6-benzyloxy-7-methoxy-2-methyl-N-(2-(thiophen-2-yl)ethyl)quinoline-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 883251-16-9
6-benzyloxy-7-methoxy-2-methylquinoline-3-carboxylic acid

: 30433-91-1
[2-(2-thyenyl)ethyl]amine

: 1426814-47-2
6-benzyloxy-7-methoxy-2-methyl-N-(2-(thiophen-2-yl)ethyl)quinoline-3-carboxamide

Guidance literature:: 6-benzyloxy-7-methoxy-2-methylquinoline-3-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

[2-(2-thyenyl)ethyl]amine; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 5h;
DOI:10.3390/molecules17055497

Reference yield:

: 621-59-0
isovanillin

: 1426814-47-2
6-benzyloxy-7-methoxy-2-methyl-N-(2-(thiophen-2-yl)ethyl)quinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C

2.1: nitric acid / 2 h / 0 - 20 °C

3.1: ammonium chloride; zinc / ethanol; water / 2 h / 20 °C

4.1: toluene-4-sulfonic acid / 0.17 h / 100 °C

4.2: 5 h / Reflux

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

5.2: 5 h / 20 °C

With nitric acid; potassium carbonate; ammonium chloride; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; zinc; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.3390/molecules17055497

Reference yield:

: 1042978-66-4
5-benzyloxy-4-methoxy-2-aminobenzaldehyde

: 1426814-47-2
6-benzyloxy-7-methoxy-2-methyl-N-(2-(thiophen-2-yl)ethyl)quinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / 0.17 h / 100 °C

1.2: 5 h / Reflux

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

2.2: 5 h / 20 °C

With benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;
DOI:10.3390/molecules17055497