[(7R,8R)-8-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]dec-7-yl]-methanol

Base Information

Chemical Name:[(7R,8R)-8-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]dec-7-yl]-methanol
CAS No.:813445-21-5
Molecular Formula:C₁₇H₂₅NO₃
Molecular Weight:291.39
Hs Code.:

Synonyms:[(7R,8R)-8-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]dec-7-yl]-methanol

Suppliers and Price of [(7R,8R)-8-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]dec-7-yl]-methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [(7R,8R)-8-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]dec-7-yl]-methanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [(7R,8R)-8-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]dec-7-yl]-methanol

There total 4 articles about [(7R,8R)-8-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]dec-7-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 813445-20-4
(7R,8R)-8-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]decane-7-carboxylic acid ethyl ester

: 813445-21-5
[(7R,8R)-8-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]dec-7-yl]-methanol

Guidance literature:: (7R,8R)-8-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]decane-7-carboxylic acid ethyl ester; With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃;

With sodium hydroxide; water; In diethyl ether; at 0 ℃;

Reference yield:

: 14160-65-7,77793-24-9,122090-88-4
ethyl 8-oxo-1,4-dioxaspiro[4.5]decane-7-carboxylate

: 813445-21-5
[(7R,8R)-8-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]dec-7-yl]-methanol

Guidance literature:: Multi-step reaction with 4 steps

1: ytterbium(III) triflate / benzene / Reflux

2: sodium tris(acetoxy)borohydride; acetic acid / acetonitrile

3: sodium t-butanolate / tetrahydrofuran

4: lithium aluminium tetrahydride / diethyl ether

With lithium aluminium tetrahydride; sodium tris(acetoxy)borohydride; acetic acid; sodium t-butanolate; ytterbium(III) triflate; In tetrahydrofuran; diethyl ether; acetonitrile; benzene;
DOI:10.1016/j.bmcl.2011.12.057

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 813445-21-5
[(7R,8R)-8-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]dec-7-yl]-methanol

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / tetrahydrofuran / Reflux

2: ytterbium(III) triflate / benzene / Reflux

3: sodium tris(acetoxy)borohydride; acetic acid / acetonitrile

4: sodium t-butanolate / tetrahydrofuran

5: lithium aluminium tetrahydride / diethyl ether

With lithium aluminium tetrahydride; sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; sodium t-butanolate; ytterbium(III) triflate; In tetrahydrofuran; diethyl ether; acetonitrile; benzene;
DOI:10.1016/j.bmcl.2011.12.057