4-[3-chloro-4-(2-diethylaminoacetamido)anilino]-6-cyclohexylmethyloxycarbonylaminoquinazoline

Base Information

Chemical Name:4-[3-chloro-4-(2-diethylaminoacetamido)anilino]-6-cyclohexylmethyloxycarbonylaminoquinazoline
CAS No.:1454806-12-2
Molecular Formula:C₂₈H₃₅ClN₆O₃
Molecular Weight:539.077
Hs Code.:

Synonyms:4-[3-chloro-4-(2-diethylaminoacetamido)anilino]-6-cyclohexylmethyloxycarbonylaminoquinazoline

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Chemical Property of 4-[3-chloro-4-(2-diethylaminoacetamido)anilino]-6-cyclohexylmethyloxycarbonylaminoquinazoline

Chemical Property:

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Technology Process of 4-[3-chloro-4-(2-diethylaminoacetamido)anilino]-6-cyclohexylmethyloxycarbonylaminoquinazoline

There total 10 articles about 4-[3-chloro-4-(2-diethylaminoacetamido)anilino]-6-cyclohexylmethyloxycarbonylaminoquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.1%

: 1454806-14-4
4-[3-chloro-4-(2-diethylaminoacetamido)anilino]-6-aminoquinazoline

: 6099-86-1
cyclohexylmethyl chlorocarbonate

: 1454806-12-2
4-[3-chloro-4-(2-diethylaminoacetamido)anilino]-6-cyclohexylmethyloxycarbonylaminoquinazoline

Guidance literature:: With dmap; In chloroform; at 0 - 20 ℃; for 20h;
DOI:10.1002/cmdc.201300120

Reference yield:

: 34004-41-6
chloro-acetic acid-(2-chloro-4-nitro-anilide)

: 1454806-12-2
4-[3-chloro-4-(2-diethylaminoacetamido)anilino]-6-cyclohexylmethyloxycarbonylaminoquinazoline

Guidance literature:: Multi-step reaction with 5 steps

1: dichloromethane / 20 h / Reflux

2: iron; hydrogenchloride / ethanol; water / 4 h / 20 °C / Reflux

3: triethylamine / isopropyl alcohol / 8 h / Reflux

4: iron; hydrogenchloride / ethanol; water / 4.5 h / 20 °C / Reflux

5: dmap / chloroform / 20 h / 0 - 20 °C

With hydrogenchloride; dmap; iron; triethylamine; In ethanol; dichloromethane; chloroform; water; isopropyl alcohol;
DOI:10.1002/cmdc.201300120

Reference yield:

: 2-diethylamino-N-(2-chloro-4-nitrophenyl)acetamide

: 1454806-12-2
4-[3-chloro-4-(2-diethylaminoacetamido)anilino]-6-cyclohexylmethyloxycarbonylaminoquinazoline

Guidance literature:: Multi-step reaction with 4 steps

1: iron; hydrogenchloride / ethanol; water / 4 h / 20 °C / Reflux

2: triethylamine / isopropyl alcohol / 8 h / Reflux

3: iron; hydrogenchloride / ethanol; water / 4.5 h / 20 °C / Reflux

4: dmap / chloroform / 20 h / 0 - 20 °C

With hydrogenchloride; dmap; iron; triethylamine; In ethanol; chloroform; water; isopropyl alcohol;
DOI:10.1002/cmdc.201300120