6099-86-1

Usage

InChI:InChI=1/C8H13ClO2/c9-8(10)11-6-7-4-2-1-3-5-7/h7H,1-6H2

Upstream product

• 75-44-5 phosgene 
• 100-49-2 cyclohexylmethyl alcohol 

Downstream Products

• 1451544-43-6 4-(4-(2-(diethylamino)acetamido)anilino)-6-(cyclohexylmethoxylformamido)quinazoline 
• 1454806-12-2 4-[3-chloro-4-(2-diethylaminoacetamido)anilino]-6-cyclohexylmethyloxycarbonylaminoquinazoline 
• 913574-95-5 benzyl cis-3-fluoro-4-hydroxypiperidine-1-carboxylate 
• 845256-59-9 benzyl 3-fluoro-4-oxopiperidine-1-carboxylate 
• 1147998-34-2 phenylmethyl 4-[(trimethylsilyl)oxy]-3,6-dihydro-1(2H)-pyridinecarboxylate 
• 19099-93-5 benzyl 4-oxo-1-piperidinecarboxylate 
• 1331837-31-0 bis(cyclohexylmethyl) 3,6-bis(4-chlorophenyl)-1,2,4,5-tetrazine-1,2-dicarboxylate 
• 68253-83-8 methyl 1-(4-chlorophenyl)-1,4-dihydro-4-oxo-6-methyl pyridazine-3-carboxylate 
• 1072-95-3 cyclohexylmethyl chloride 
• 18420-36-5 -cyclohexan 
• 18420-34-3 phenyl-carbamic acid cyclohexylmethyl ester 

Relevant academic research and scientific papers

COLCHICINE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PREPARING SAID DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING SAID DERIVATIVES

The present invention relates to colchicine derivatives expressed in chemical formula 1, or to pharmaceutically acceptable salts thereof, to a method for preparing said derivatives, and to a pharmaceutical composition comprising said derivatives. The colchicine derivatives according to the present invention exhibit superior immunomodulatory effects as compared with conventional immunomodulators or colchicines, and therefore can be valuably used as an immunomodulator for modulating an acute or chronic immune response in organ transplantation.

Functionalization of single-walled carbon nanotubes with (R-)oxycarbonyl nitrenes

Sidewall functionalization of single-walled carbon nanotubes (SWCNTs) via the addition of (R-)-oxycarbonyl nitrenes allows for the covalent binding of a variety of different groups such as alkyl chains, aromatic groups, dendrimers, crown ethers, and oligoethylene glycol units. Such additions lead to a considerable increase in the solubility in organic solvents such as 1,1,2,2-tetrachloroethane (TCE), dimethyl sulfoxide (DMSO), and 1,2-dichlorobenzene (ODCB). The highest solubilities of 1.2 mg/mL were found for SWCNT adducts with nitrenes containing crown ether of oligoethylene glycol moieties in DMSO and TCE, respectively. The presence of chelating donor groups within the addends allowed for the complexation of Cu2+ and Cd2+. Atomic force microscopy (AFM) and transmission electron microscopy (TEM) revealed that the functionalized tubes form thin bundles with typical diameters of 10 nm. The presence of thin bundles in solution is supported by 1H NMR spectroscopy. The elemental composition of the functionalized SWCNT was determined by X-ray photoelectron spectroscopy (XPS). The use of Raman and electron absorption spectroscopy (UV/Vis-nIR) showed that the electronic properties of the SWCNTs are mostly retained after functionalization, indicating a low degree of addition within this series of SWCNT derivatives.

Beta lactam compounds and their use as inhibitors of tryptase

Compounds of the formulas: are disclosed. These compounds inhibit tryptase as well as other enzyme systems or are selective tryptase inhibitors and are useful as antiinflammatory agents particularly in the treatment of chronic asthma.