7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid, 13-cyclohexyl-3-methoxy-6-[2-(methoxycarbonyl)phenyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid, 13-cyclohexyl-3-methoxy-6-[2-(methoxycarbonyl)phenyl]-, 1,1-dimethylethyl ester
CAS No.:1112187-86-6
Molecular Formula:C₃₇H₃₉NO₅
Molecular Weight:577.72
Hs Code.:

Synonyms:7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid, 13-cyclohexyl-3-methoxy-6-[2-(methoxycarbonyl)phenyl]-, 1,1-dimethylethyl ester

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Chemical Property of 7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid, 13-cyclohexyl-3-methoxy-6-[2-(methoxycarbonyl)phenyl]-, 1,1-dimethylethyl ester

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Technology Process of 7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid, 13-cyclohexyl-3-methoxy-6-[2-(methoxycarbonyl)phenyl]-, 1,1-dimethylethyl ester

There total 3 articles about 7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid, 13-cyclohexyl-3-methoxy-6-[2-(methoxycarbonyl)phenyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 945627-36-1
7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid, 13-cyclohexyl-3-methoxy-6-(tributylstannyl)-, 1,1-dimethylethyl ester

: 610-94-6
2-bromobenzoic acid methyl ester

: 1112187-86-6
7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid, 13-cyclohexyl-3-methoxy-6-[2-(methoxycarbonyl)phenyl]-, 1,1-dimethylethyl ester

Guidance literature:: bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; at 60 - 100 ℃; for 18h;

Reference yield:

: 958002-18-1
1H-indole-6-carboxylic acid, 3-cyclohexyl-2-(2-formyl-4-methoxyphenyl)-, 1,1-dimethylethyl ester

: 1112187-86-6
7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid, 13-cyclohexyl-3-methoxy-6-[2-(methoxycarbonyl)phenyl]-, 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine / 1,4-dioxane / 0.25 h / 120 °C / Microwave irradiation

2: 2,2'-azobis(isobutyronitrile); triethylamine / benzene / 13.33 h / Heating / reflux

3: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 18 h / 60 - 100 °C

With 2,2'-azobis(isobutyronitrile); 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; benzene;

Reference yield:

: 945627-35-0
7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid, 13-cyclohexyl-3-methoxy-6-(phenylsulfonyl)-, 1,1-dimethylethyl ester

: 1112187-86-6
7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid, 13-cyclohexyl-3-methoxy-6-[2-(methoxycarbonyl)phenyl]-, 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 2,2'-azobis(isobutyronitrile); triethylamine / benzene / 13.33 h / Heating / reflux

2: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 18 h / 60 - 100 °C

With 2,2'-azobis(isobutyronitrile); triethylamine; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; benzene;