6-fluoro-1-isopropyl-2-[(1-benzylpiperidin-4-yl)carbonyl]-1,2,3,4-tetrahydroisoquinoline hydrochloride

Base Information

Chemical Name:6-fluoro-1-isopropyl-2-[(1-benzylpiperidin-4-yl)carbonyl]-1,2,3,4-tetrahydroisoquinoline hydrochloride
CAS No.:1344029-53-3
Molecular Formula:C₂₅H₃₁FN₂O*ClH
Molecular Weight:430.993
Hs Code.:

Synonyms:6-fluoro-1-isopropyl-2-[(1-benzylpiperidin-4-yl)carbonyl]-1,2,3,4-tetrahydroisoquinoline hydrochloride

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Chemical Property of 6-fluoro-1-isopropyl-2-[(1-benzylpiperidin-4-yl)carbonyl]-1,2,3,4-tetrahydroisoquinoline hydrochloride

Chemical Property:

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Technology Process of 6-fluoro-1-isopropyl-2-[(1-benzylpiperidin-4-yl)carbonyl]-1,2,3,4-tetrahydroisoquinoline hydrochloride

There total 4 articles about 6-fluoro-1-isopropyl-2-[(1-benzylpiperidin-4-yl)carbonyl]-1,2,3,4-tetrahydroisoquinoline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1344029-15-7
4-[(6-fluoro-1-isopropyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl]piperidine

: 100-52-7
benzaldehyde

: 1344029-53-3
6-fluoro-1-isopropyl-2-[(1-benzylpiperidin-4-yl)carbonyl]-1,2,3,4-tetrahydroisoquinoline hydrochloride

Guidance literature:: 4-[(6-fluoro-1-isopropyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl]piperidine; benzaldehyde; With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃; for 15h; Cooling with ice;

With hydrogenchloride; In ethyl acetate;
DOI:10.1248/cpb.59.1029

Reference yield:

: 1085540-14-2
N-[2-(3-fluorophenyl)ethyl]-2-methylpropanamide

: 1344029-53-3
6-fluoro-1-isopropyl-2-[(1-benzylpiperidin-4-yl)carbonyl]-1,2,3,4-tetrahydroisoquinoline hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: phosphorus pentoxide; trichlorophosphate / 5,5-dimethyl-1,3-cyclohexadiene / 2 h / Reflux

2: sodium tetrahydroborate / ethanol / 2 h / 20 °C / Cooling with ice

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 120 h / 20 °C / Cooling with ice

4: hydrogenchloride / ethyl acetate / 24 h / 20 °C / Cooling with ice

5: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 15 h / 20 °C / Cooling with ice

With hydrogenchloride; sodium tetrahydroborate; phosphorus pentoxide; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trichlorophosphate; In 5,5-dimethyl-1,3-cyclohexadiene; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 1: Bischler-Napieralski reaction;
DOI:10.1248/cpb.59.1029

Reference yield:

: 1085543-18-5
6-fluoro-1-isopropyl-1,2,3,4-tetrahydroisoquinoline hydrochloride

: 1344029-53-3
6-fluoro-1-isopropyl-2-[(1-benzylpiperidin-4-yl)carbonyl]-1,2,3,4-tetrahydroisoquinoline hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 120 h / 20 °C / Cooling with ice

2: hydrogenchloride / ethyl acetate / 24 h / 20 °C / Cooling with ice

3: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 15 h / 20 °C / Cooling with ice

With hydrogenchloride; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.59.1029