methyl 1-((6-(trans-4-tert-butylcyclohexyloxy)quinolin-2-yl)methyl)piperidine-4-carboxylate

Base Information

Chemical Name:methyl 1-((6-(trans-4-tert-butylcyclohexyloxy)quinolin-2-yl)methyl)piperidine-4-carboxylate
CAS No.:1393449-08-5
Molecular Formula:C₂₇H₃₈N₂O₃
Molecular Weight:438.61
Hs Code.:

Synonyms:methyl 1-((6-(trans-4-tert-butylcyclohexyloxy)quinolin-2-yl)methyl)piperidine-4-carboxylate

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Chemical Property of methyl 1-((6-(trans-4-tert-butylcyclohexyloxy)quinolin-2-yl)methyl)piperidine-4-carboxylate

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Technology Process of methyl 1-((6-(trans-4-tert-butylcyclohexyloxy)quinolin-2-yl)methyl)piperidine-4-carboxylate

There total 4 articles about methyl 1-((6-(trans-4-tert-butylcyclohexyloxy)quinolin-2-yl)methyl)piperidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 2971-79-1
isonipecotic acid methyl ester

: 1266116-57-7
6-((trans-4-(tert-butyl)cyclohexyl)oxy)quinoline-2-carbaldehyde

: 1393449-08-5
methyl 1-((6-(trans-4-tert-butylcyclohexyloxy)quinolin-2-yl)methyl)piperidine-4-carboxylate

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃; for 1.16667h;

Reference yield:

: 613-21-8
6-hydroxyquinaldine

: 1393449-08-5
methyl 1-((6-(trans-4-tert-butylcyclohexyloxy)quinolin-2-yl)methyl)piperidine-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 72 h / 20 °C / Cooling with ice

2: di-tert-butyl peroxide; selenium(IV) oxide / 1,4-dioxane / 50 °C

3: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 1.17 h / 20 °C

With selenium(IV) oxide; di-tert-butyl peroxide; di-isopropyl azodicarboxylate; sodium tris(acetoxy)borohydride; acetic acid; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

Reference yield:

: 1266116-56-6
6-((trans-4-(tert-butyl)cyclohexyl)oxy)-2-methylquinoline

: 1393449-08-5
methyl 1-((6-(trans-4-tert-butylcyclohexyloxy)quinolin-2-yl)methyl)piperidine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: di-tert-butyl peroxide; selenium(IV) oxide / 1,4-dioxane / 50 °C

2: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 1.17 h / 20 °C

With selenium(IV) oxide; di-tert-butyl peroxide; sodium tris(acetoxy)borohydride; acetic acid; In 1,4-dioxane; dichloromethane;