tert-butyl 2-bromo-4-(difluoromethoxy)phenylcarbamate

Base Information

• Chemical Name: tert-butyl 2-bromo-4-(difluoromethoxy)phenylcarbamate
• CAS No.: 1198109-74-8
• Molecular Formula: C₁₂H₁₄BrF₂NO₃
• Molecular Weight: 338.149
• Mol file: 1198109-74-8.mol

Synonyms:tert-butyl 2-bromo-4-(difluoromethoxy)phenylcarbamate

Chemical Property of tert-butyl 2-bromo-4-(difluoromethoxy)phenylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of tert-butyl 2-bromo-4-(difluoromethoxy)phenylcarbamate

There total 3 articles about tert-butyl 2-bromo-4-(difluoromethoxy)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

tert-butyl 4-(difluoromethoxy)phenylcarbamate (1198109-73-7) → tert-butyl 2-bromo-4-(difluoromethoxy)phenylcarbamate (1198109-74-8)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; acetonitrile; at 60 ℃; for 18h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 2-bromo-4-(difluoromethoxy)phenylcarbamate (1198109-74-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / acetonitrile / 18 h / 50 °C

2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane; acetonitrile / 18 h / 60 °C

With N-Bromosuccinimide; triethylamine; dibenzoyl peroxide; In tetrachloromethane; acetonitrile;

Reference yield:

4-difluoromethoxyaniline (22236-10-8) → tert-butyl 2-bromo-4-(difluoromethoxy)phenylcarbamate (1198109-74-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / acetonitrile / 18 h / 50 °C

2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane; acetonitrile / 18 h / 60 °C

With N-Bromosuccinimide; triethylamine; dibenzoyl peroxide; In tetrachloromethane; acetonitrile;

upstream raw materials:

tert-butyl 4-(difluoromethoxy)phenylcarbamate

di-tert-butyl dicarbonate

4-difluoromethoxyaniline

Downstream raw materials:

N-(2-bromo-4-(difluoromethoxy)phenyl)-6-chloro-2-methylpyrimidine-4,5-diamine

9-(2-bromo-4-(difluoromethoxy)phenyl)-6-chloro-2,8-dimethyl-9H-purine

9-(2-bromo-4-(difluoromethoxy)phenyl)-N-(dicyclopropylmethyl)-2,8-dimethyl-9H-purine-6-amine

2-(6-(dicyclopropylmethylamino)-2,8-dimethyl-9H-purin-9-yl)-5-(difluoromethoxy)benzonitrile

Refernces