22236-10-8

Usage

Chemical Properties

Clear colorless to orange-brown liquid

InChI:InChI=1/C7H7F2NO/c8-7(9)11-6-3-1-5(10)2-4-6/h1-4,7H,10H2

Upstream product

• 1544-86-1 1-difluoromethoxy-4-nitrobenzene 
• 7440-66-6 zinc 
• 4472-44-0 2-chloro-4,6-dimethylpyrimidine 
• 75-45-6 Chlorodifluoromethane 
• 123-30-8 4-amino-phenol 
• 128140-82-9 1-(difluoromethoxy)-4-iodobenzene 

Downstream Products

• 51679-46-0 2-(4-Difluoromethoxy-phenylamino)-benzoic acid 
• 235101-34-5 6-(difluoromethoxy)benzo[d]thiazol-2-amine 
• 380343-29-3 2-[3-(4-difluoromethoxy-phenyl)-thioureido]-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester 
• 871586-76-4 ethyl 6-difluoromethoxy-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylate 
• 342779-35-5 3-(4-difluoromethoxy-phenyl)-2-thioxo-2,3,5,6,7,8-hexahydro-1H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one 
• 326014-85-1 3-(4-difluoromethoxy-phenyl)-2-[2-(4-fluoro-phenyl)-2-oxo-ethylsulfanyl]-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one 
• 827031-10-7 N-(4-difluoromethoxyphenyl)-2-methylquinazolin-4-amine 
• 859825-64-2 7-benzyl-N-(4-(difluoromethoxy)phenyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-amine 
• 1141892-47-8 (4-difluoromethoxyphenyl)(5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)amine 
• 1328951-82-1 N-(4-difluoromethoxyphenyl)-4-(2-oxoimidazolidin-1-yl)benzenesulfonamide 
• 1242558-74-2 C₁₄H₁₇F₂NO₃ 
• 949993-23-1 C₁₈H₂₄F₂N₂O₄ 

Relevant academic research and scientific papers

Preparation method of 4- polyfluoro methoxy O-phenylenediamine (by machine translation)

The method disclosed by the invention 4 - is characterized in that the aminophenol, and the alkali :(1) are reacted at a mole ratio of the 1:0.8-1.5, 20-40 °C compound 0.1-24h with the halogen, and, the halogen compound in the solvent to 1:1.0-3.0,20-120 °C, 0.01-20Mpa react with 1-72h. 1-72h the 4 - 1:0.8-30.0 ammonia solution ;(2)4 - or the halogen compound at a mole ratio of the compound of the 1:0.2 - 2.5 amino phenol, 30-80 °C with 0.1-24h;(3)4 - the halogen and the halogen compound in the solvent 0.1-10%, 50-200 °C, 0.01-10Mpa: 4 . (by machine translation)

Copper(I)-catalyzed amination of aryl halides in liquid ammonia

The amination of aryl halides in liquid ammonia (LNH3) is catalyzed by a copper(I) salt/ascorbate system to yield primary aromatic amines in good to excellent yields. The low concentrations of catalyst required and the ease of product isolation suggest that this process has potential industrial applications. Commonly used ligands for analogous metal-catalyzed reactions are not effective. The rate of amination of iodobenzene in liquid ammonia is first order in copper(I) catalyst concentration. The small Hammett I? = 0.49 for the amination of 4-substituted iodobenzenes in liquid ammonia at 25 °C indicates that the C-I bond is not significantly broken in the transition state structure and that there is a small generation of negative charge in the aryl ring, which is compatible with the oxidative addition of the copper ion being rate limiting.

Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof

The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (e.g., indazoles and benzothiazoles), which act as ligands for the α7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

NICOTINIC ALPHA-7 RECEPTOR LIGANDS AND PREPARATION AND USES THEREOF

The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds which act as ligands for the α7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, AND 1,2-BENZISOTHIAZOLES, AND PREPARATION AND USES THEREOF

The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds for example, indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, which act as ligands for the α7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

1H-INDAZOLES, BENZOTHIAZOLES, 1,2-BENZOISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND CHROMONES AND PREPARATION AND USES THEREOF

The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (indazoles and benzothiazoles), which act as ligands for the α7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof

The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (indazoles and benzothiazoles), which act as ligands for the α7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

2-imino-1,3-dithietanes, their use as pesticides

There are described new 2-imino-1,3-dithietanes of general formula I STR1 in which R is the group STR2 in which A is CFHal, C(CH3)C1-4 -alkyl, C(CH3)CHal3, C(CH3)CF2 Cl, C(CH3)CFCl2, C2 H4, C2 H3 Hal, C2 H2 Hal2, C2 HHal3, C2 F2 Cl2, C2 F4 or C2 F3 Cl, in which Hal is F or Cl, Y is nitrogen or CH, R1 is fluoro-C1-12 -alkyl, fluoro-C2-12 -alkenyl, fluoro-C2-12 -alkynyl, fluorocyclopropyl or fluorocyclopropylmethyl; X is oxygen or sulphur, 2 is defined in the specification and n is 0, 1 or 2, as well as their acid addition salts, a process for their preparation and their use as pesticides. The new compounds are especially useful as nematicides.

Anilinopyrimidine fungicides

There are described new pyrimidine derivatives of the general formula I STR1 in which n is 0, 1 or 2; R1 is (a) the group --CXR5, where X is oxygen or sulphur and R5 is hydrogen, a nitrogen or sulphur containing heterocyclic group, which can contain other hetero atoms, optionally substituted alkenyl, acyl, alkoxycarbonyl, alkyl substituted by aryloxy, or optionally substituted mono- or dialkylamino; or R5 is the group --NHR6, where R6 is substituted amino, substituted carbamoyl, optionally substituted alkylsulphonyl, acyl or arylsulphonyl, and when n is 0 or when X is sulphur, R5 can also be alkyl, haloalkyl, aryl, aralkyl, alkoxycarbonylalkyl or arylamino; (b) cyano or the group --CXYR7, where X and Y are the same or different and are oxygen, sulphur or optionally substituted imino and R7 is optionally substituted alkyl, aryl, acyl or a nitrogen or sulphur containing heterocyclic group, which can contain other hetero atoms; or (c) when n is 1 or 2 and at least one R4 group is haloalkoxy, R1 can be hydrogen; R2 and R3 are the same or different and are alkyl, and R4 is alkyl, alkoxy, halogen, haloalkyl, haloalkoxy, nitro or cyano. The compounds have fungicidal activity.