22236-10-8

Basic information

• Product Name: 4-(Difluoromethoxy)aniline
• Synonyms: TIMTEC-BB SBB003981;P-DIFLUOROMETHOXYANILINE;BUTTPARK 45\03-44;ART-CHEM-BB B014415;AKOS BBS-00000568;ALPHA,ALPHA-DIFLUORO-P-ANISIDINE;AKOS B014415;4-AMINO-ALPHA,ALPHA-DIFLUOROANISOLE
• CAS NO: 22236-10-8
• Molecular Formula: C₇H₇F₂NO
• Molecular Weight: 159.13
• EINECS: -0
• Product Categories: API intermediates;Amines;C7;Nitrogen Compounds;Building Blocks;Chemical Synthesis;Difluoromethyl;Fluorinated Building Blocks;Nitrogen Compounds;Organic Building Blocks;Organic Fluorinated Building Blocks;Fluorine series
• Mol File: 22236-10-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 231 °C(lit.)
• Flash Point: >230 °F
• Appearance: Clear colorless to orange-brown liquid
• Density: 1.283 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0928mmHg at 25°C
• Refractive Index: n20/D 1.505(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 4.15±0.10(Predicted)
• BRN: 2804462
• CAS DataBase Reference: 4-(Difluoromethoxy)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Difluoromethoxy)aniline(22236-10-8)
• EPA Substance Registry System: 4-(Difluoromethoxy)aniline(22236-10-8)

Safety Data

• Hazard Codes: Xn,T,Xi
• Statements: 22-36/37/38-43
• Safety Statements: 26-36/37
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 2
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 22236-10-8(Hazardous Substances Data)

Usage

Chemical Properties

Clear colorless to orange-brown liquid

InChI:InChI=1/C7H7F2NO/c8-7(9)11-6-3-1-5(10)2-4-6/h1-4,7H,10H2

Upstream product

• 1544-86-1 1-difluoromethoxy-4-nitrobenzene 
• 4472-44-0 2-chloro-4,6-dimethylpyrimidine 
• 75-45-6 Chlorodifluoromethane 
• 123-30-8 4-amino-phenol 
• 128140-82-9 1-(difluoromethoxy)-4-iodobenzene 
• 7440-66-6 zinc 

Downstream Products

• 128924-22-1 C₁₅H₁₄F₂N₂O₄S 
• 638192-11-7 ethyl(4-difluoromethoxyphenyl)carbamate 
• 827031-10-7 N-(4-difluoromethoxyphenyl)-2-methylquinazolin-4-amine 
• 871492-77-2 (R)-3-[4-(4-difluoromethoxy-phenylamino)-piperidin-1-yl]-butyronitrile 
• 1093100-61-8 N₈-(3-(9H-purin-6-yl)pyridin-2-yl)-N₄-(4-(difluoromethoxy)phenyl)-7-methylquinazoline-4,8-diamine 
• 1198109-73-7 tert-butyl 4-(difluoromethoxy)phenylcarbamate 
• 1198109-55-5 6-chloro-4-N-(4-difluoromethoxyphenyl)-2-methylpyrimidine-4,5-diamine hydrochloride 
• 1228535-32-7 3-(4-difluoromethoxy-phenylazo)-pentane-2,4-dione 
• 1238700-28-1 3-{[4-(difluoromethoxy)phenyl]hydrazono}pentane-2,4-dione 
• 1198115-49-9 C₁₂H₁₁ClF₂N₄O 
• 1198108-95-0 dicyclopropylmethyl-[9-(4-difluoromethoxyphenyl)-2,8-dimethyl-9H-purin-6-yl]-amine 
• 1198109-56-6 6-chloro-9-(4-difluoromethoxyphenyl)-2,8-dimethyl-9H-purine 

Relevant articles and documents

Preparation method of 4- polyfluoro methoxy O-phenylenediamine (by machine translation)

The method disclosed by the invention 4 - is characterized in that the aminophenol, and the alkali :(1) are reacted at a mole ratio of the 1:0.8-1.5, 20-40 °C compound 0.1-24h with the halogen, and, the halogen compound in the solvent to 1:1.0-3.0,20-120 °C, 0.01-20Mpa react with 1-72h. 1-72h the 4 - 1:0.8-30.0 ammonia solution ;(2)4 - or the halogen compound at a mole ratio of the compound of the 1:0.2 - 2.5 amino phenol, 30-80 °C with 0.1-24h;(3)4 - the halogen and the halogen compound in the solvent 0.1-10%, 50-200 °C, 0.01-10Mpa: 4 . (by machine translation)

Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof

The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (e.g., indazoles and benzothiazoles), which act as ligands for the α7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, AND 1,2-BENZISOTHIAZOLES, AND PREPARATION AND USES THEREOF

The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds for example, indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, which act as ligands for the α7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.