2-[(4aR,6S,7S,8R,8aR)-7,8-Bis-benzyloxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-ethanol

Base Information

Chemical Name:2-[(4aR,6S,7S,8R,8aR)-7,8-Bis-benzyloxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-ethanol
CAS No.:199792-19-3
Molecular Formula:C₃₀H₃₄O₇
Molecular Weight:506.596
Hs Code.:

Synonyms:2-[(4aR,6S,7S,8R,8aR)-7,8-Bis-benzyloxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-ethanol

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Chemical Property of 2-[(4aR,6S,7S,8R,8aR)-7,8-Bis-benzyloxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-ethanol

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Technology Process of 2-[(4aR,6S,7S,8R,8aR)-7,8-Bis-benzyloxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-ethanol

There total 9 articles about 2-[(4aR,6S,7S,8R,8aR)-7,8-Bis-benzyloxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 199791-97-4
[(4aR,6S,7S,8R,8aR)-7,8-Bis-benzyloxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-acetic acid methyl ester

: 199792-19-3
2-[(4aR,6S,7S,8R,8aR)-7,8-Bis-benzyloxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-ethanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 0 ℃; for 0.5h;
DOI:10.1016/S0040-4039(97)10107-1 DOI:10.1016/S0040-4020(97)10254-X

Reference yield:

: 199791-95-2
allyl 2,3-O-dibenzyl-4,6-O-p-methoxybenzylidene-D-glucopyranoside

: 199792-19-3
2-[(4aR,6S,7S,8R,8aR)-7,8-Bis-benzyloxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: 1) i-Pr₂NEt, (Ph₃P)3RhCl, 2) HgO, HgCl₂ / 1) EtOH, reflux, 2 h, 2) acetone, H₂O, room temperature, 1 h

2: 99 percent / benzene / 24 h / Heating

3: 100 percent / NaH / tetrahydrofuran / 16 h / Ambient temperature

4: 98 percent / LiAlH₄ / diethyl ether; tetrahydrofuran / 0.5 h / 0 °C

With Wilkinson's catalyst; lithium aluminium tetrahydride; sodium hydride; N-ethyl-N,N-diisopropylamine; mercury dichloride; mercury(II) oxide; In tetrahydrofuran; diethyl ether; benzene;
DOI:10.1016/S0040-4020(97)10254-X

Reference yield:

: (E)-(4S,5R)-4,5-Bis-benzyloxy-5-[(4R,5R)-5-hydroxy-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-pent-2-enoic acid methyl ester

: 199792-19-3
2-[(4aR,6S,7S,8R,8aR)-7,8-Bis-benzyloxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / NaH / tetrahydrofuran / 16 h / Ambient temperature

2: 98 percent / LiAlH₄ / diethyl ether; tetrahydrofuran / 0.5 h / 0 °C

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; diethyl ether;
DOI:10.1016/S0040-4020(97)10254-X